Evidence map›Paper›PMID 26447600›Full record

ArticleInternational journal of impotence research

Additive effects of Artemisia capillaris extract and scopoletin on the relaxation of penile corpus cavernosum smooth muscle.

B R Choi, S K Kumar, C Zhao, L T Zhang, C Y Kim, S W Lee, J-H Jeon, K K Soní, I So, S H Kim and 3 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in International journal of impotence research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Journal of clinical medicine · 2022
    Article
  2. Article
  3. Frontiers in endocrinology · 2021
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

B R ChoiDepartment of Urology, Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University, Jeonju, Republic of Korea.
S K KumarDepartment of Urology, Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University, Jeonju, Republic of Korea.
C ZhaoDepartment of Urology, Renji Hospital, Jiao Tong University School of Medicine, and Shanghai Institute of Andrology, Shanghai, China.
L T ZhangDepartment of Urology, Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University, Jeonju, Republic of Korea.
C Y KimDepartment of Pharmacognosy, Hangyang University, Ansan, Republic of Korea.
S W LeeDepartment of Urology, Sungkyunkwan University Medical School, Seoul, Republic of Korea.
J-H JeonDepartment of Physiology, Seoul National University Medical School, Seoul, Republic of Korea.
K K Soní
I SoDepartment of Physiology, Seoul National University Medical School, Seoul, Republic of Korea.
S H KimDepartment of Physiology, Diabetic Research Center, Chonbuk National University Medical School, Jeonju, Republic of Korea.
N C ParkDepartment of Urology, Pusan National University Hospital, Busan, Republic of Korea.
H K KimDepartment of Urology, Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University, Jeonju, Republic of Korea.
J K ParkDepartment of Urology, Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University, Jeonju, Republic of Korea.
Jeonbuk National University · KRSeoul National University · KRPusan National University Hospital · KRRenji Hospital · CNSungkyunkwan University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective was to investigate the cellular effect and action mechanism of Artemisia capillaris extract (ACE) and its component, scopoletin, on penile corpus cavernosum smooth muscle (PCCSM). In vitro study with PCCSM, the precontracted PCCSM with phenylephrine was treated with ACE or scopoletin. Cyclic nucleotides in the perfusate were measured by radioimmunoassay and expression of protein and mRNA of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase in the perfused PCCSM were measured by western blot and real-time PCR, respectively. The interaction of ACE or scopoletin with udenafil was also evaluated. ACE and scopoletin exerted a significant and concentration-dependent relaxation in PCCSM. The perfusion with ACE or scopoletin significantly increased cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) and the perfusion with ACE or scopoletin increased the expression of eNOS mRNA and protein. Furthermore, ACE or scopoletin enhanced udenafil-inducing relaxation in PCCSM. ACE and scopoletin relaxed the PCCSM mainly by activating nitric oxide-cGMP system and cAMP pathway and they may be additive therapeutic candidates for ED patients who do not completely respond to udenafil.

Indexed as

AnimalsArtemisiaBenzenesulfonamidesBlotting, WesternCyclic AMPCyclic GMPDrug InteractionsMaleMuscle RelaxationMuscle, SmoothNitric Oxide Synthase Type INitric Oxide Synthase Type IIIPenisPhosphodiesterase 5 InhibitorsPlant ExtractsPyrimidinesBenzenesulfonamidesCyclic AMPCyclic GMPNitric Oxide Synthase Type INitric Oxide Synthase Type IIIPhosphodiesterase 5 InhibitorsPlant ExtractsPyrimidinesRNA, MessengerScopoletinSulfonamidesudenafil

Identifiers

PMID26447600
OpenAlexW2301338559

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.