ArticleAmerican journal of physiology. Renal physiology2016
Dynamic contrast-enhanced quantitative susceptibility mapping with ultrashort echo time MRI for evaluating renal function.
Article in American journal of physiology. Renal physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 22 citations in OpenAlex.
- Quantitative Susceptibility Mapping Shows Size-dependent Focused Ultrasound-mediated Therapeutic Delivery to Naive Brain and Gliomas in Mice.Radiology · 2026Article
- Feasibility of quantitative susceptibility mapping (QSM) of the human kidney.Magma (New York, N.Y.) · 2021Article
- Nephron number and its determinants: a 2020 update.Pediatric nephrology (Berlin, Germany) · 2021Article
- Feasibility of QSM in the human placenta.Magnetic resonance in medicine · 2021Article
- Hardware Considerations for Preclinical Magnetic Resonance of the Kidney.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Exercise-induced calf muscle hyperemia: Rapid mapping of magnetic resonance imaging using deep learning approach.Physiological reports · 2020Article
- High-resolution MRI of kidney microstructures at 7.05 T with an endo-colonic Wireless Amplified NMR detector.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2019Article
- Dynamic contrast-enhanced MRI promotes early detection of toxin-induced acute kidney injury.American journal of physiology. Renal physiology · 2019Article
- Multicenter reproducibility of quantitative susceptibility mapping in a gadolinium phantom using MEDI+0 automatic zero referencing.Magnetic resonance in medicine · 2019Article
- MRI gradient-echo phase contrast of the brain at ultra-short TE with off-resonance saturation.NeuroImage · 2018Article
- Measurement of Murine Single-Kidney Glomerular Filtration Rate Using Dynamic Contrast-Enhanced MRI.Magnetic resonance in medicine · 2018Article
- Novel contrast mixture achieves contrast resolution of human bladder wall suitable for T1 mapping: applications in interstitial cystitis and beyond.International urology and nephrology · 2018Article
- MRI-Based Quantification of Magnetic Susceptibility in Gel Phantoms: Assessment of Measurement and Calculation Accuracy.Radiology research and practice · 2018Article
- MRI tools for assessment of microstructure and nephron function of the kidney.American journal of physiology. Renal physiology · 2016Review
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8 authors at 4 institutions in 1 country.
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Abstract
Dynamic contrast-enhanced (DCE) MRI can provide key insight into renal function. DCE MRI is typically achieved through an injection of a gadolinium (Gd)-based contrast agent, which has desirable T1 quenching and tracer kinetics. However, significant T2* blooming effects and signal voids can arise when Gd becomes very concentrated, especially in the renal medulla and pelvis. One MRI sequence designed to alleviate T2* effects is the ultrashort echo time (UTE) sequence. In the present study, we observed T2* blooming in the inner medulla of the mouse kidney, despite using UTE at an echo time of 20 microseconds and a low dose of 0.03 mmol/kg Gd. We applied quantitative susceptibility mapping (QSM) and resolved the signal void into a positive susceptibility signal. The susceptibility values [in parts per million (ppm)] were converted into molar concentrations of Gd using a calibration curve. We determined the concentrating mechanism (referred to as the concentrating index) as a ratio of maximum Gd concentration in the inner medulla to the renal artery. The concentrating index was assessed longitudinally over a 17-wk course (3, 5, 7, 9, 13, 17 wk of age). We conclude that the UTE-based DCE method is limited in resolving extreme T2* content caused by the kidney's strong concentrating mechanism. QSM was able to resolve and confirm the source of the blooming effect to be the large positive susceptibility of concentrated Gd. UTE with QSM can complement traditional magnitude UTE and offer a powerful tool to study renal pathophysiology.
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