Evidence map›Paper›PMID 26447157›Full record

Observational studyThe American journal of clinical nutrition2015

Gluten consumption during late pregnancy and risk of celiac disease in the offspring: the TEDDY birth cohort.

Ulla Uusitalo, Hye-Seung Lee, Carin Andrén Aronsson, Jimin Yang, Suvi M Virtanen, Jill Norris, Daniel Agardh, Environmental Determinants of the Diabetes in the Young (TEDDY) study group

Open access · bronzeAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The American journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  4. Review
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Mechanisms by which gut microorganisms influence food sensitivities.Nature reviews. Gastroenterology & hepatology · 2019
    Review
  10. Article
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Ulla UusitaloHealth Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL;
Hye-Seung LeeHealth Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL;
Carin Andrén AronssonThe Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden;
Jimin YangHealth Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL;
Suvi M VirtanenUnit of Nutrition, National Institute for Health and Welfare, Helsinki, Finland, Tampere, Finland, Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland, and Science Center of Pirkanmaa Hospital District, Tampere, Finland; and.
Jill NorrisDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO.
Daniel AgardhThe Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden; daniel.agardh@med.lu.se.
Environmental Determinants of the Diabetes in the Young (TEDDY) study group
University of South Florida · USLund University · SEColorado School of Public Health · USFinnish Institute for Health and Welfare · FI

Funding

Data Coordinating Center (DCC)for the Consortium for Identification of EnvironmenUC4DK095300 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2011 to 2011
$56.0M
Data Coordinating CenterU01DK063790 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2002 to 2006
$50.1M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
NIDDK Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4)UC4DK117483 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2017 to 2020
$30.4M
Establish a Data Coordinating Center (DCC) for the Consortium for Identification UC4DK100238 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2014 to 2014
$28.9M
The Study of Epigenetics and Infections in The Environmental Determinants of Diabetes in the Young (TEDDY)UC4DK112243 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2016 to 2016
$27.0M
Data Coordinating Center (DCC) for the Consortium for Identification of Environmental Determinants of Diabetes in the Young (TEDDY) StudyUC4DK106955 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2015 to 2015
$20.0M
The Environmental Determinants of Diabetes in Young (TEDDY0U01DK063863 · NIDDK · HOSPITAL DISTRICT OF SOUTHWEST FINLAND · PI TOPPARI, JORMA · 2003 to 2022
$13.5M
The Environmental Triggers of Diabetes (TEDDY) in SwedenU01DK063861 · NIDDK · UNIVERSITY OF WASHINGTON · PI LERNMARK, AKE · 2003 to 2022
$13.4M
THE TEDDY STUDY - COLORADO CLINICAL CENTERU01DK063821 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 2003 to 2022
$12.3M
The TEDDY Study: Georgia/Florida Clinical CenterU01DK063865 · NIDDK · MEDICAL COLLEGE OF GEORGIA (MCG) · PI MCINDOE, RICHARD A. · 2003 to 2022
$12.3M
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001082NCATS NIH HHS UL1 TR001427NIDDK NIH HHS U01 DK63790NIDDK NIH HHS U01 DK63821NIDDK NIH HHS U01 DK63829NIDDK NIH HHS U01 DK63836NIDDK NIH HHS U01 DK63861NIDDK NIH HHS U01 DK63863NIDDK NIH HHS U01 DK63865NIDDK NIH HHS UC4 DK063821NIDDK NIH HHS UC4 DK100238NIDDK NIH HHS UC4 DK106955NIDDK NIH HHS UC4 DK112243NIDDK NIH HHS UC4 DK117483NIDDK NIH HHS UC4 DK63821NIDDK NIH HHS UC4 DK63829NIDDK NIH HHS UC4 DK63836NIDDK NIH HHS UC4 DK63861NIDDK NIH HHS UC4 DK63863NIDDK NIH HHS UC4 DK63865NIDDK NIH HHS UC4DK95300NLM NIH HHS HHSN267200700014C
6 · The paper itself

Abstract

backgroundMaternal diet during pregnancy has been proposed to increase the risk of autoimmune diseases.

objectiveThe objective was to investigate the association between maternal consumption of gluten-containing foods during late pregnancy and subsequent risk of celiac disease in the offspring.

designGenetically susceptible children prospectively followed from birth were screened annually for tissue transglutaminase autoantibodies (tTGAs). Children testing persistently positive for tTGAs were further evaluated for celiac disease. Diagnosis of celiac disease was confirmed by intestinal biopsy or was considered likely if the mean tTGA concentration was >100 units in 2 consecutive samples. A questionnaire on the mother's diet in late pregnancy was completed by 3-4.5 mo postpartum. Mothers were divided into 3 groups based on the tertiles of their consumption of gluten-containing foods (servings/d). The association between maternal gluten-containing food consumption and the risk of celiac disease was studied by using a time-to-event analysis.

resultsAt the time of analysis, 359 (5%) of the 6546 children developed celiac disease. Compared with the middle category of maternal gluten-containing food consumption (servings/d), low (HR: 0.87; 95% CI: 0.67, 1.13; P = 0.296) and high (HR: 0.84; 95% CI: 0.65, 1.09; P = 0.202) consumption was not associated with risk of celiac disease in the child after adjustment for country, human leukocyte antigen genotype, family history of celiac disease, maternal education, and sex of the child. Median maternal daily consumption frequency of gluten-containing foods was higher (P < 0.0001) in Finland (5.3; IQR: 3.9-6.9), Germany (4.3; IQR: 3.1-5.5), and Sweden (3.7; IQR: 2.8-4.9) than in the United States (3.4; IQR: 2.3-4.9). No significant interaction was found between country of residence and the mothers' consumption of gluten-containing foods in relation to risk of celiac disease.

conclusionThe frequency of gluten-containing food consumption during late pregnancy is not associated with risk of celiac disease in the offspring.

Indexed as

Maternal Nutritional Physiological PhenomenaAutoantibodiesCeliac DiseaseCohort StudiesDietary ProteinsDiet, Gluten-FreeEuropeFamily HealthFemaleFollow-Up StudiesGlutensHumansInfant, NewbornMalePregnancyPregnancy Trimester, ThirdAutoantibodiesDietary ProteinsGlutensTransglutaminasesceliac diseaseglutenmaternal consumptionoffspringpregnancy

Identifiers

PMID26447157
PMCPMC4625598
OpenAlexW1892292591

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.