Evidence map›Paper›PMID 26446953›Full record

ReviewScience translational medicine2015

Companion animals: Translational scientist's new best friends.

Amir Kol, Boaz Arzi, Kyriacos A Athanasiou, Diana L Farmer, Jan A Nolta, Robert B Rebhun, Xinbin Chen, Leigh G Griffiths, Frank J M Verstraete, Christopher J Murphy and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Science translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amir KolDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Boaz ArziDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Kyriacos A AthanasiouDepartment of Biomedical Engineering, University of California, Davis, Davis, CA 95616, U.S.A. Department of Orthopedic Surgery, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
Diana L FarmerDepartment of Surgery, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
Jan A NoltaDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, Davis, CA 95616, USA. Department of Internal Medicine, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
Robert B RebhunDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Xinbin ChenDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA. Department of Internal Medicine, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
Leigh G GriffithsDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Frank J M VerstraeteDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Christopher J MurphyDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA. Department of Ophthalmology and Vision Science, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
Dori L BorjessonDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA. dlborjesson@ucdavis.edu.

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
MECHANISM OF P73 DEPENDENT TUMOR SUPPRESSIONR01CA081237 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XINBIN · 1999 to 2022
$6.8M
Modulation of Signal Transduction by Nano-TopographyR01EY016134 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI MURPHY, CHRISTOPHER JOHN, THOMASY, SARA MICHELLE · 2006 to 2023
$5.1M
Mechanism of p53-Mediated Tumor SuppressionR01CA076069 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XINBIN · 2002 to 2017
$4.5M
Biophysical Cues and Corneal Wound HealingR01EY019970 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MURPHY, CHRISTOPHER JOHN · 2011 to 2020
$3.5M
The transcriptional activity of p63, a p53 family memberR01CA102188 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XINBIN · 2003 to 2012
$2.9M
Xenogeneic Scaffolds for Heart Valve Tissue EngineeringR01HL115205 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GRIFFITHS, LEIGH GARETH · 2013 to 2017
$1.9M
The role of DNA polymerase eta in DNA damage response and p53 activationR01CA123227 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XINBIN · 2010 to 2014
$1.4M
The relationship between epidermal growth factor receptor and hedgehog signalingK01OD011111 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI REBHUN, ROBERT B · 2012 to 2015
$517k
An Animal Model of Chronic Oral Inflammation for Stem Cell-Based TherapyR21DE024711 · NIDCR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BORJESSON, DORI L. · 2014 to 2015
$312k
NCI NIH HHS P30 CA093373NCI NIH HHS R01 CA076069NCI NIH HHS R01 CA081237NCI NIH HHS R01 CA102188NCI NIH HHS R01 CA123227NEI NIH HHS R01 EY016134NEI NIH HHS R01 EY019970NHLBI NIH HHS R01 HL115205NIDCR NIH HHS 1R21DE024711-01NIDCR NIH HHS R21 DE024711NIH HHS K01 OD011111
6 · The paper itself

Abstract

Knowledge and resources derived from veterinary medicine represent an underused resource that could serve as a bridge between data obtained from diseases models in laboratory animals and human clinical trials. Naturally occurring disease in companion animals that display the defining attributes of similar, if not identical, diseases in humans hold promise for providing predictive proof of concept in the evaluation of new therapeutics and devices. Here we outline comparative aspects of naturally occurring diseases in companion animals and discuss their current uses in translational medicine, benefits, and shortcomings. Last, we envision how these natural models of disease might ultimately decrease the failure rate in human clinical trials and accelerate the delivery of effective treatments to the human clinical market.

Indexed as

Disease Models, AnimalTranslational Research, BiomedicalAnimalsClinical Trials as TopicHumans

Identifiers

PMID26446953
PMCPMC4806851

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.