Trial reportProgress in orthodontics2015
Effect of single-dose low-level helium-neon laser irradiation on orthodontic pain: a split-mouth single-blind placebo-controlled randomized clinical trial.
Trial report in Progress in orthodontics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Does audiovisual information affect anxiety and perceived pain levels in miniscrew application? - a within-person randomized controlled trial.Progress in orthodontics · 2019Trial
- Laser-Assisted Orthodontic Tooth Movement in Saudi Population: A Prospective Clinical Intervention of Low-Level Laser Therapy in the 1st Week of Pain Perception in Four Treatment Modalities.Pain research & management · 2019Trial
- Review
- Effect of photobiomodulation therapy on orthodontic-induced inflammatory root resorption in male albino rats.BMC oral health · 2025Article
- Written information versus multimedia education: A randomized trial on anxiety at the onset of orthodontic treatment in adolescents.Korean journal of orthodontics · 2025Article
- Efficacy and Safety of Cold Atmospheric Plasma-Assisted Therapy for Herpes Zoster: A Randomized, Parallel, Positive-Controlled, Non-inferiority Multicenter Clinical Trial.Dermatology and therapy · 2025Article
- Effect of low-level laser therapy on pain perception and anxiety levels in conventional local anesthesia injection.Journal of dental anesthesia and pain medicine · 2025Article
- Article
- Efficacy of Photobiomodulation Therapy for Orthodontic Pain Control Following the Placement of Elastomeric Separators: A Randomized Clinical Trial.Journal of lasers in medical sciences · 2021Article
- Laser Assisted Surgical and Orthodontic Treatment of a Dilacerated Impacted Maxillary Incisor: A Case Report.Frontiers in dentistry · 2021Article
- Low-Level Laser Therapy: A Noninvasive Method of Relieving Postactivation Orthodontic Pain-A Randomized Controlled Clinical Trial.Journal of pharmacy & bioallied sciences · 2019Article
- Optimal management of orthodontic pain.Journal of pain research · 2018Review
- Methodologies in Orthodontic Pain Management: A Review.The open dentistry journal · 2017Article
- Orofacial Pains.Pain research & management · 2017Article
- Evaluation of Low-Level Laser Therapy on Orthodontic Tooth Movement: A Randomized Control Study.Contemporary clinical dentistryArticle
- The Protocol of Low-level Laser Therapy in Orthodontic Practice: A Scoping Review of Literature.Journal of International Society of Preventive & Community DentistryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPain is the most common complication of orthodontic treatment. Low-level laser therapy (LLLT) has been suggested as a new analgesic treatment free of the adverse effects of analgesic medications. However, it is not studied thoroughly, and the available studies are quite controversial. Moreover, helium neon (He-Ne) laser has not been assessed before.
methodsThis split-mouth placebo-controlled randomized clinical trial was performed on 16 male and 14 female orthodontic patients requiring bilateral upper canine retraction. The study was performed at a private clinic in Sari, Iran, in 2014. It was single blind: patients, orthodontist, and personnel were blinded of the allocations, but the laser operator (periodontist) was not blinded. Once canine retractor was activated, a randomly selected maxillary quarter received a single dose of He-Ne laser irradiation (632.8 nm, 10 mw, 6 j/cm(2) density). The other quarter served as the placebo side, treated by the same device but powered off. In the first, second, fourth, and seventh days, blinded patients rated their pain sensed on each side at home using visual analog scale (VAS) questionnaires. There was no harm identified during or after the study. Pain changes were analyzed using two- and one-way repeated-measures ANOVA, Bonferroni, and t-test (α = 0.01, β > 0.99). This trial was not registered. It was self-funded by the authors.
resultsSixteen males and 11 females remained in the study (aged 12-21). Average pain scores sensed in all 4 intervals on control and laser sides were 4.06 ± 2.85 and 2.35 ± 1.77, respectively (t-test P < 0.0001). One-way ANOVA showed significant pain declines over time, in each group (P < 0.0001). Two-way ANOVA showed significant effects for LLLT (P < 0.0001) and time (P = <0.0001).
conclusionsSingle-dose He-Ne laser therapy might reduce orthodontic pain caused by retracting maxillary canines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.