ArticleMolecular biology and evolution2016
Recombination Rate Variation Modulates Gene Sequence Evolution Mainly via GC-Biased Gene Conversion, Not Hill-Robertson Interference, in an Avian System.
Article in Molecular biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 74 citations in OpenAlex.
- Evolution of GC-biased gene conversion by natural selection.Genetics · 2025Article
- Compensatory Evolution Following Deleterious Episodes of GC-biased Gene Conversion in Rodents.Molecular biology and evolution · 2025Article
- Comparative Phylogenetics Reveal Clade-specific Drivers of Recombination Rate Evolution Across Vertebrates.Molecular biology and evolution · 2025Article
- Purging of Highly Deleterious Mutations Through an Extreme Bottleneck.Molecular biology and evolution · 2025Article
- Causes and consequences of a complex recombinational landscape in the antGenome research · 2024Article
- High prevalence of PRDM9-independent recombination hotspots in placental mammals.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Increased Positive Selection in Highly Recombining Genes Does not Necessarily Reflect an Evolutionary Advantage of Recombination.Molecular biology and evolution · 2024Article
- The role of recombination dynamics in shaping signatures of direct and indirect selection across theProceedings. Biological sciences · 2024Article
- Rapid Targeted Assembly of the Proteome Reveals Evolutionary Variation of GC Content in Avian Lice.Bioinformatics and biology insights · 2024Article
- Domestication affects sex-biased gene expression evolution in the duck.Royal Society open science · 2023Article
- The Heterogeneity in the Landscape of Gene Dominance in Maize is Accompanied by Unique Chromatin Environments.Molecular biology and evolution · 2022Article
- Extreme variation in recombination rate and genetic diversity along the Sylvioidea neo-sex chromosome.Molecular ecology · 2022Article
- GC-biased gene conversion in X-chromosome palindromes conserved in human, chimpanzee, and rhesus macaque.G3 (Bethesda, Md.) · 2021Article
- Integrating Sequence Capture and Restriction Site-Associated DNA Sequencing to Resolve Recent Radiations of Pelagic Seabirds.Systematic biology · 2021Article
- The Effects of GC-Biased Gene Conversion on Patterns of Genetic Diversity among and across Butterfly Genomes.Genome biology and evolution · 2021Article
- Quantitative Approach to Fish Cytogenetics in the Context of Vertebrate Genome Evolution.Genes · 2021Article
- Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared with mice andGenome research · 2021Article
- Tissue-specific patterns of regulatory changes underlying gene expression differences amongGenome research · 2020Article
- Divergent genes in gerbils: prevalence, relation to GC-biased substitution, and phenotypic relevance.BMC evolutionary biology · 2020Article
- Runaway GC Evolution in Gerbil Genomes.Molecular biology and evolution · 2020Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
The ratio of nonsynonymous to synonymous substitution rates (ω) is often used to measure the strength of natural selection. However, ω may be influenced by linkage among different targets of selection, that is, Hill-Robertson interference (HRI), which reduces the efficacy of selection. Recombination modulates the extent of HRI but may also affect ω by means of GC-biased gene conversion (gBGC), a process leading to a preferential fixation of G:C ("strong," S) over A:T ("weak," W) alleles. As HRI and gBGC can have opposing effects on ω, it is essential to understand their relative impact to make proper inferences of ω. We used a model that separately estimated S-to-S, S-to-W, W-to-S, and W-to-W substitution rates in 8,423 avian genes in the Ficedula flycatcher lineage. We found that the W-to-S substitution rate was positively, and the S-to-W rate negatively, correlated with recombination rate, in accordance with gBGC but not predicted by HRI. The W-to-S rate further showed the strongest impact on both dN and dS. However, since the effects were stronger at 4-fold than at 0-fold degenerated sites, likely because the GC content of these sites is farther away from its equilibrium, ω slightly decreases with increasing recombination rate, which could falsely be interpreted as a consequence of HRI. We corroborated this hypothesis analytically and demonstrate that under particular conditions, ω can decrease with increasing recombination rate. Analyses of the site-frequency spectrum showed that W-to-S mutations were skewed toward high, and S-to-W mutations toward low, frequencies, consistent with a prevalent gBGC-driven fixation bias.
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