ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016
Trabecular bone score as a skeletal fragility index in acromegaly patients.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Differences between bone health parameters in adults with acromegaly and growth hormone deficiency: A systematic review.Best practice & research. Clinical endocrinology & metabolism · 2023Pooled it
- Prevalence of clinical signs, symptoms and comorbidities at diagnosis of acromegaly: a systematic review in accordance with PRISMA guidelines.Pituitary · 2023Pooled it
- Determinants of skeletal fragility in acromegaly: a systematic review and meta-analysis.Pituitary · 2022Pooled it
- Bone mineral density assessment by DXA in disease-associated osteoporosis: the limitations.Frontiers in endocrinology · 2026Review
- Bone mineral density and trabecular bone score in adults with primary immunodeficiencies: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Evaluation of bone density and microstructure by DXA, TBS and HR-pQCT: an assessment of cortical porosity and its association with vertebral fractures in patients with acromegaly.Journal of endocrinological investigation · 2025Article
- Assessment of Bone Health in Adult Patients with Inflammatory Bowel Disease: A Single-Center Cohort Study.Journal of clinical medicine · 2025Article
- Review
- Novel approach to bone comorbidity in resistant acromegaly.Pituitary · 2024Review
- Acromegaly and Bone: An Update.Endocrinology and metabolism (Seoul, Korea) · 2023Review
- Persistent Deficits in Bone Quality in Treated Acromegaly: Evidence From Assessments of Microstructure.Journal of the Endocrine Society · 2023Article
- Skeletal complications in acromegaly.Reumatologia · 2023Review
- Age, body composition parameters and glycaemic control contribute to trabecular bone score deterioration in acromegaly more than disease activity.Frontiers in endocrinology · 2023Article
- The effect of body size and composition on lumbar spine trabecular bone score in morphologically diverse subjects.PloS one · 2023Article
- Vertebral Fractures in Acromegaly: A Systematic Review.Journal of clinical medicine · 2022Review
- Update on trabecular bone score.Archives of endocrinology and metabolism · 2022Review
- Trabecular Bone Score as a Reliable Measure of Lumbar Spine Bone Microarchitecture in Acromegalic Patients.Journal of clinical medicine · 2022Article
- Vertebral fractures, trabecular bone score and their determinants in chronic hypoparathyroidism.Journal of endocrinological investigation · 2022Article
- Trabecular Bone Score and Osteoprotegerin as Useful Tools in the Assessment of Bone Deterioration in Acromegaly.Frontiers in endocrinology · 2022Article
- Low sclerostin levels after long-term remission of acromegaly.Endocrine · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryLumbar spine trabecular bone score (TBS) was significantly decreased in active acromegaly patients. TBS may be useful to assess the skeletal fragility in acromegaly in which bone mineral density (BMD) is not sufficient to represent bone strength and explain the high incidence of fragility fractures in acromegaly patients.
introductionAlthough the data on BMD are controversial, patients with acromegaly have an increased risk of fragility fracture. We examined the lumbar spine TBS to explain the skeletal deterioration in acromegaly patients.
methodsWe included 14 men and 19 women acromegaly patients who underwent dual-energy X-ray absorptiometry at the time of diagnosis from 2000 to 2014 at Seoul National University Hospital. Ninety-nine age-, sex- and body mass index-matched controls were recruited. Biochemical parameters, lumbar spine TBS, and BMD at all sites were measured. Gonadal status was evaluated at diagnosis.
resultsLumbar spine TBS was lower in acromegaly patients than in controls in both genders (1.345 ± 0.121 vs. 1.427 ± 0.087, P = 0.005 in men; 1.356 ± 0.082 vs. 1.431 ± 0.071, P = 0.001 in women). In contrast, BMD at all sites did not differ between the two groups. Hypogonadal acromegaly patients (men, n = 9; women, n = 12) had lower TBS values compared with controls both in men and women (all P < 0.05), although BMD at all sites were similar for the two groups. In eugonadal acromegaly patients, lumbar spine TBS was lower than in women controls only (P = 0.041).
conclusionsSkeletal microarchitecture was deteriorated in acromegaly patients as assessed by TBS, which seems to be a consequence of growth hormone excess as well as hypogonadism, especially in women.
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