ArticleAging cell2016
Predicting all-cause mortality from basic physiology in the Framingham Heart Study.
Article in Aging cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Combining modifiable risk factors and risk of dementia: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Frailty and blood pressure in older adults: rethinking risk and treatment strategies.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Article
- How is Big Data reshaping preclinical aging research?Lab animal · 2023Review
- Article
- Association Between Electrocardiographic Age and Cardiovascular Events in Community Settings: The Framingham Heart Study.Circulation. Cardiovascular quality and outcomes · 2023Article
- Appraisal of Cardiovascular Risk Factors, Biomarkers, and Ocular Imaging in Cardiovascular Risk Prediction.Current cardiology reviews · 2023Review
- Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice.eLife · 2022Article
- Life-long body mass index trajectories and mortality in two generations.Annals of epidemiology · 2021Article
- Evidence for the Universal Blood Pressure Goal of <130/80 mm Hg Is Strong: Controversies in Hypertension - Pro Side of the Argument.Hypertension (Dallas, Tex. : 1979) · 2020Review
- Hypertension (Blood Pressure) and Lifetime Risk of Target Organ Damage.Current hypertension reports · 2020Review
- Low birth weight trends: possible impacts on the prevalences of hypertension and chronic kidney disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Review
- Preterm Birth Is Associated With Increased Blood Pressure in Young Adults: Important Opportunities for Blood Pressure Management.Journal of the American Heart Association · 2019Article
- Review
- Hypertension and cardiovascular disease: Is a treatment strategy focused on high risk sufficient?Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Blood Pressure Management: Beyond the Guidelines.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Sirtuin 5 is required for mouse survival in response to cardiac pressure overload.The Journal of biological chemistry · 2017Article
- Heterogeneity of Human Aging and Its Assessment.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- The Longitudinal Study of Aging in Human Young Adults: Knowledge Gaps and Research Agenda.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Dynamics of biomarkers in relation to aging and mortality.Mechanisms of ageing and development · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Using longitudinal data from a cohort of 1349 participants in the Framingham Heart Study, we show that as early as 28-38 years of age, almost 10% of variation in future lifespan can be predicted from simple clinical parameters. Specifically, we found diastolic and systolic blood pressure, blood glucose, weight, and body mass index (BMI) to be relevant to lifespan. These and similar parameters have been well-characterized as risk factors in the relatively narrow context of cardiovascular disease and mortality in middle to old age. In contrast, we demonstrate here that such measures can be used to predict all-cause mortality from mid-adulthood onward. Further, we find that different clinical measurements are predictive of lifespan in different age regimes. Specifically, blood pressure and BMI are predictive of all-cause mortality from ages 35 to 60, while blood glucose is predictive from ages 57 to 73. Moreover, we find that several of these parameters are best considered as measures of a rate of 'damage accrual', such that total historical exposure, rather than current measurement values, is the most relevant risk factor (as with pack-years of cigarette smoking). In short, we show that simple physiological measurements have broader lifespan-predictive value than indicated by previous work and that incorporating information from multiple time points can significantly increase that predictive capacity. In general, our results apply equally to both men and women, although some differences exist.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.