Evidence map›Paper›PMID 26446643›Full record

ArticleYonsei medical journal2015

The Impact of CDH13 Polymorphism and Statin Administration on TG/HDL Ratio in Cardiovascular Patients.

Jung Ran Choi, Yangsoo Jang, Sungjoo Kim Yoon, Jong Keun Park, Sungbin Richard Sorn, Mi-Young Park, Myoungsook Lee

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Yonsei medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Genes · 2021
    Review
  2. Article
  3. Association of CDH13 Gene Polymorphism and Metabolic Syndrome in Gambian Population.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2021
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jung Ran ChoiDepartment of Food and Nutrition, and Research Institute of Obesity Sciences, Sungshin Women's University, Seoul, Korea.
Yangsoo JangCardiovascular Genome Center, Cardiology Division, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea. jangys1212@yuhs.ac.
Sungjoo Kim YoonResearch Institute of Molecular Genetics, The Catholic University of Korea, Seoul, Korea.
Jong Keun ParkResearch Institute of Molecular Genetics, The Catholic University of Korea, Seoul, Korea.
Sungbin Richard SornSchool of Medicine, The Catholic University of Korea, Seoul, Korea.
Mi-Young ParkInstitute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul, Korea.
Myoungsook LeeDepartment of Food and Nutrition, and Research Institute of Obesity Sciences, Sungshin Women's University, Seoul, Korea. mlee@sungshin.ac.kr.
Catholic University of Korea · KRSungshin Women's University · KRSeoul National University · KRYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAdiponectin is expressed in adipose tissue, and is affected by smoking, obesity, and genetic factors, such as CDH13 polymorphism, contributing to the development of coronary vascular diseases (CVDs). MATERIALS AND

methodsWe investigated the effect of genetic variations of CDH13 (rs3865188) on blood chemistry and adiponectin levels in 345 CVD patients undergoing statin-free or statin treatment.

resultsGenetic variation in CDH13 was significantly correlated with several clinical factors, including adiponectin, diastolic blood pressure, triglyceride (TG), and insulin levels. Subjects with the T allele (mutant form) had significantly lower adiponectin levels than those with the A allele. Total cholesterol (TC), low-density lipoprotein cholesterol (LDLc), TG/high-density lipoprotein cholesterol (HDLc) ratio, and HDL3b subtype were markedly decreased in statin treated subjects regardless of having the A or T allele. TG and TG/HDL in the statin-free group with TT genotype of the rs3865188 was higher than in the others but they were not different in the statin-treated subjects. We observed a significant difference in adiponectin levels between patients with the A and T alleles in the statin-free group; meanwhile, no difference in adiponectin levels was noted in the statin group. Plasma levels of other cytokines, leptin, visfatin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), were not different among the CDH13 genotypes according to statin administration. Body mass index (BMI), TG, insulin, HDL3b, and TG/HDL ratio showed negative correlations with adiponectin levels.

conclusionPlasma adiponectin levels and TG/HDL ratio were significantly different according to variants of CDH13 and statin administration in Korean patients with CVD.

Indexed as

AdiponectinAdultAgedAllelesBlood PressureBody Mass IndexCadherinsCholesterolCholesterol, LDLFemaleGenotypeHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInsulinInterleukin-6LeptinAdiponectinADIPOQ protein, humanCadherinsCholesterolCholesterol, LDLHDL-triglycerideHydroxymethylglutaryl-CoA Reductase InhibitorsIL6 protein, humanInsulinInterleukin-6LeptinLipoproteins, HDLTriglyceridesTumor Necrosis Factor-alphaAdiponectinCDH13HDL3bstatinTG/HDL

Identifiers

PMID26446643
PMCPMC4630049
OpenAlexW1949380012

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.