Evidence map›Paper›PMID 26446589›Full record

SynthesisJournal of thrombosis and thrombolysis2016

Gender differences of venous thromboembolism risk after total hip and total knee arthroplasty: a meta-analysis.

Yue Lu, Zhen-Yu Zhou, Ya-Ke Liu, Hong-Lin Chen, Hui-Lin Yang, Fan Liu

Abstract readMeta-AnalysisReview
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In one paragraph

Synthesis in Journal of thrombosis and thrombolysis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Gender Differences do not Influence the Blood Coagulopathy in Patients Undergoing Total Knee Arthroplasty: A Retrospective Thromboelastography Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yue LuFirst Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Zhen-Yu ZhouDepartment of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China.
Ya-Ke LiuDepartment of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China.
Hong-Lin ChenNantong University, Nantong, Jiangsu, People's Republic of China.
Hui-Lin YangFirst Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Fan LiuDepartment of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China. pphss@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed a meta-analysis to evaluate gender differences of venous thromboembolism (VTE) risk after total hip (THA) and total knee arthroplasty (TKA). We searched PubMed and Web of Knowledge from their beginning to 25 July 2015. Pooled odds ratio (OR) and 95 % confidence interval (CI) for VTE risk were calculated. Twenty studies with 7,892,585 patients were included in our study. The VTE incidence ranged from 0.27 to 61.0 %. The sex ratio (male/female) was 0.623 (3,016,648/4,839,785) in no VTE group versus 0.492 (11,926/24,226) in VTE group. The pooled OR was 1.184 (95 % CI 1.070-1.310; Z = 3.28, P = 0.001). The Begg's test (z = 1.46, P = 0.144) and the Egger's test (t = 0.58, P = 0.571), and the funnel plot suggested there was no significant publication bias. Sensitivity analysis by omitted a study with largest simple size showed the pooled OR was 1.166 (95 % CI 1.051-1.294; Z = 2.91, P = 0.004) by random-effects model. Meta-regression showed VTE risk was not related with THA and TKA incidence (t = 0.35, P = 0.732). Our meta-analysis showed female patients have slightly higher risk of VTE than male patients after THA and TKA.

Indexed as

Models, BiologicalSex CharacteristicsArthroplasty, Replacement, HipArthroplasty, Replacement, KneeFemaleHumansMalePostoperative ComplicationsRisk FactorsSex FactorsVenous ThromboembolismGender differenceMeta-analysisTotal hip arthroplastyTotal knee arthroplastyVenous thromboembolism

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.