Evidence map›Paper›PMID 26446558›Full record

ArticleJournal of the Royal Society, Interface2015

Morpho-elasticity of inflammatory fibrosis: the case of capsular contracture.

Martine Ben Amar, Min Wu, Miguel Trejo, Michael Atlan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Physics of growing biological tissues: the complex cross-talk between cell activity, growth and resistance.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2019
    Review
  8. Strong triaxial coupling and anomalous Poisson effect in collagen networks.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  9. Article
  10. Morphoelasticity in the development of brown algaJournal of the Royal Society, Interface · 2017
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Martine Ben AmarLaboratoire de Physique Statistique, Ecole Normale Supérieure, UPMC Univ Paris 06, Université Paris Diderot, CNRS, 24 rue Lhomond, 75005 Paris, France Institut Universitaire de Cancérologie, Faculté de médecine, Université Pierre et Marie Curie-Paris 6, 91 Bd de l'Hôpital, 75013 Paris, France benamar@lps.ens.fr.
Min WuLaboratoire de Physique Statistique, Ecole Normale Supérieure, UPMC Univ Paris 06, Université Paris Diderot, CNRS, 24 rue Lhomond, 75005 Paris, France Institut Universitaire de Cancérologie, Faculté de médecine, Université Pierre et Marie Curie-Paris 6, 91 Bd de l'Hôpital, 75013 Paris, France.
Miguel TrejoLaboratoire de Physique et Mécanique des Milieux Hétérogènes (PMMH), UMR CNRS 7636; PSL - ESPCI, 10 rue Vauquelin, 75005 Paris, France.
Michael AtlanHopital Tenon APHP, Université Pierre et Marie Curie-Paris 6, 3 rue de la Chine, 75020 Paris, France.
Centre National de la Recherche Scientifique · FRDélégation Paris 7 · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory fibrosis is a wound-healing reaction of the immune system in mammals against aggression. After a signalling cascade, fibroblasts and potentially myofibroblasts make a stiff collagenous tissue inside the body that modifies the original healthy tissue. We focus here on the implant-induced fibrosis that aims to encapsulate the implant with a typical fibrous tissue called the capsule. Focusing on breast capsules, we aim to understand the mechanical properties of these tissues, to test the validity of fibre models that have been established in other contexts such as arteries. For this purpose, we perform force-extension experiments and show that mechanical constitutive laws of these tissues are especially difficult to derive, because models are sensitive to fibre orientation and dispersion, independently of the variation between individuals. In addition, fibre breakdown, and possibly remodelling, occur during the extension experiments. However, the high stiffness of the capsular tissue, compared with the healthy tissue, added to the fact that an inflammatory process has no reason to cease, is at the origin of large compressive stresses in vivo, which explains the pain and unaesthetic deformity. We evaluate the stresses responsible for the pain and the buckling instability, which have no reason to stop if the inflammation persists.

Indexed as

ContractureInflammationAnimalsBiopsyBreastCollagenElasticityFemaleFibroblastsFibrosisForeign-Body ReactionHumansModels, BiologicalMyofibroblastsPhagocytesSignal TransductionCollagenfibrosisinflammationnonlinear elasticitypathologypatient biopsysoft tissues

Identifiers

PMID26446558
PMCPMC4614484
OpenAlexW2178528780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.