ArticleWorld journal of surgery2016
Correlation Between Surgical Extent and Prognosis in Node-Negative, Early-Stage Papillary Thyroid Carcinoma Originating in the Isthmus.
Article in World journal of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Recurrence risk of differentiated thyroid cancer treated with total or hemithyroidectomy: systematic review and meta-analysis.European thyroid journal · 2026Pooled it
- Total thyroidectomy versus lobectomy for papillary thyroid cancer: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Isthmic papillary thyroid microcarcinoma: clinicopathological features and prognostic factors following isthmusectomy based on tumor size stratification.Discover oncology · 2026Article
- Prognosis and surgical outcomes of isthmusectomy for cN0 solitary Low-Risk papillary thyroid microcarcinoma in the isthmus.Endocrine · 2026Article
- Exploring the Appropriate Surgical Extent for Papillary Thyroid Carcinoma of the Isthmus: A Multicenter Retrospective Cohort Study.Biomedicines · 2025Article
- Hemithyroidectomy versus total thyroidectomy for patients with differentiated thyroid cancer: a systematic review and meta-analysis.Gland surgery · 2025Article
- Thermal ablation for papillary thyroid carcinoma in the isthmus: a systematic review and meta-analysis.Gland surgery · 2025Article
- The effect of thyroid nodule location in ultrasound on the diagnosis of papillary thyroid carcinoma.Discover oncology · 2025Article
- Thermal ablation for papillary thyroid microcarcinoma in the isthmus: a systematic review and meta-analysis.Endocrine connections · 2025Article
- Should there be a paradigm shift for the evaluation of isthmic thyroid nodules?Journal of endocrinological investigation · 2024Article
- Total thyroidectomy versus less-than-total thyroidectomy for papillary thyroid carcinoma of isthmus: a systematic review and meta-analysis.Gland surgery · 2023Article
- Investigating the impact of tumor location and size on the risk of recurrence for papillary thyroid carcinoma in the isthmus.Cancer medicine · 2023Article
- Risk prediction for central lymph node metastasis in isolated isthmic papillary thyroid carcinoma by nomogram: A retrospective study from 2010 to 2021.Frontiers in endocrinology · 2022Article
- Differences in the clinical characteristics of papillary thyroid microcarcinoma located in the isthmus ≤5 mm and >5mm in diameter.Frontiers in oncology · 2022Article
- Are clinicopathological features of the isthmic thyroid nodule different from nodules in thyroid lobes? A single center experience.Archives of endocrinology and metabolism · 2021Article
- Pathological analysis and surgical modalities selection of cT1N0M0 solitary papillary thyroid carcinoma in the isthmus.Gland surgery · 2021Article
- Surgical Extent of Central Lymph Node Dissection for Papillary Thyroid Carcinoma Located in the Isthmus: A Propensity Scoring Matched Study.Frontiers in endocrinology · 2021Article
- Comparison of Outcomes Following Thyroid Isthmusectomy, Unilateral Thyroid Lobectomy, and Total Thyroidectomy in Patients with Papillary Thyroid Microcarcinoma of the Thyroid Isthmus: A Retrospective Study at a Single Center.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Evaluation of Ultrasound-Guided Radiofrequency Ablation as a Treatment Option for Papillary Thyroid Microcarcinoma in the Isthmus: A Retrospective Study.Frontiers in endocrinology · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between surgical extent and prognosis in papillary thyroid carcinoma originating in the isthmus is unclear.
methodsWe included 233 patients with early-stage, node-negative papillary thyroid cancer originating in the isthmus; 126 were treated by lobectomy plus isthmusectomy with ipsilateral central neck dissection and 97 were treated by total thyroidectomy with bilateral central neck dissection. Subgroup analysis was performed according to tumor size (≤ 1 vs. >1 cm) to evaluate whether tumor size had a significant impact on determining the optimal extent of surgery in our cohort.
resultsTotal thyroidectomy patients had longer recurrence-free survival (RFS) than those treated by lobectomy plus isthmusectomy. Subgroup analysis showed that this was true only for tumors >1 cm. In multivariate analysis, total thyroidectomy was an independent risk factor for RFS only for tumors >1 cm.
conclusionsLobectomy plus isthmusectomy may be optimal for early-stage, node-negative papillary thyroid carcinoma originating in the isthmus for tumors ≤ 1 cm; total thyroidectomy might be better for tumors >1 cm.
Indexed as
Identifiers
26446448What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.