ArticleScientific reports2015
Extensible byssus of Pinctada fucata: Ca(2+)-stabilized nanocavities and a thrombospondin-1 protein.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Recombinant Proteins: A Molecular Tool to Understand Marine Adhesion and to Advance Biomaterials.Advanced healthcare materials · 2026Review
- Stage-Specific Transcriptomes of the MusselGenes · 2023Article
- Extensible and self-recoverable proteinaceous materials derived from scallop byssal thread.Nature communications · 2022Article
- Characterization of Thrombospondin Type 1 Repeat in Haliotis diversicolor and Its Possible Role in Osteoinduction.Marine biotechnology (New York, N.Y.) · 2021Article
- Structure, function and parallel evolution of the bivalve byssus, with insights from proteomes and the zebra mussel genome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Genome-Wide Identification and Characterization ofMarine drugs · 2019Article
- Resolving the relationships of clams and cockles: dense transcriptome sampling drastically improves the bivalve tree of life.Proceedings. Biological sciences · 2019Article
- In Silico Analysis of Pacific Oyster (International journal of molecular sciences · 2019Article
- The discovered chimeric protein plays the cohesive role to maintain scallop byssal root structural integrity.Scientific reports · 2018Article
- Byssus Structure and Protein Composition in the Highly Invasive Fouling MusselFrontiers in physiology · 2018Article
- Highly diversified expansions shaped the evolution of membrane bound proteins in metazoans.Scientific reports · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extensible byssus is produced by the foot of bivalve animals, including the pearl oyster Pinctada fucata, and enables them to attach to hard underwater surfaces. However, the mechanism of their extensibility is not well understood. To understand this mechanism, we analyzed the ultrastructure, composition and mechanical properties of the P. fucata byssus using electron microscopy, elemental analysis, proteomics and mechanical testing. In contrast to the microstructures of Mytilus sp. byssus, the P. fucata byssus has an exterior cuticle without granules and an inner core with nanocavities. The removal of Ca(2+) by ethylenediaminetetraacetic acid (EDTA) treatment expands the nanocavities and reduces the extensibility of the byssus, which is accompanied by a decrease in the β-sheet conformation of byssal proteins. Through proteomic methods, several proteins with antioxidant and anti-corrosive properties were identified as the main components of the distal byssus regions. Specifically, a protein containing thrombospondin-1 (TSP-1), which is highly expressed in the foot, is hypothesized to be responsible for byssus extensibility. Together, our findings demonstrate the importance of inorganic ions and multiple proteins for bivalve byssus extension, which could guide the future design of biomaterials for use in seawater.
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