ArticleJournal of cell death2012
RBM10 Modulates Apoptosis and Influences TNF-α Gene Expression.
Article in Journal of cell death, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Impact of RBM10 and PD-L1 expression on the prognosis of pathologic N1-N2 epidermal growth factor receptor mutant lung adenocarcinoma.Translational lung cancer research · 2023Article
- Functional insight into a neurodevelopmental disorder caused by missense variants in an RNA-binding protein, RBM10.Journal of human genetics · 2023Article
- Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells.International journal of molecular medicine · 2022Article
- Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer.The Journal of clinical investigation · 2022Article
- NPTX1 inhibits pancreatic cancer cell proliferation and migration and enhances chemotherapy sensitivity by targeting RBM10.Oncology letters · 2022Article
- RNA Binding Motif 5 Gene Deletion Modulates Cell Signaling in a Sex-Dependent Manner but Not Hippocampal Cell Death.Journal of neurotrauma · 2022Article
- Review
- Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex.Epigenetics & chromatin · 2021Article
- RBM10, a New Regulator of p53.Cells · 2020Review
- Dengue virus targets RBM10 deregulating host cell splicing and innate immune response.Nucleic acids research · 2020Article
- RBM10 inhibits cell proliferation of lung adenocarcinoma via RAP1/AKT/CREB signalling pathway.Journal of cellular and molecular medicine · 2019Article
- Functional role of RBM10 in lung adenocarcinoma proliferation.International journal of oncology · 2019Article
- RBM10: Harmful or helpful-many factors to consider.Journal of cellular biochemistry · 2018Review
- Article
- BrainPhys® increases neurofilament levels in CNS cultures, and facilitates investigation of axonal damage after a mechanical stretch-injury in vitro.Experimental neurology · 2018Article
- Increased cell apoptosis in human lung adenocarcinoma andOncology letters · 2017Article
- Splicing arrays reveal novel RBM10 targets, including SMN2 pre-mRNA.BMC molecular biology · 2017Article
- Functional analysis reveals that RBM10 mutations contribute to lung adenocarcinoma pathogenesis by deregulating splicing.Scientific reports · 2017Article
- RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5.PloS one · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence suggests that protein encoded by the RNA Binding Motif 10 (RBM10) gene has the ability to modulate apoptosis. The objective of this study was to test this hypothesis by manipulating RBM10 expression levels and examining the downstream consequences. The results showed that transient overexpression of RBM10 correlated with significantly elevated levels of tumour necrosis factor alpha (TNF-α) mRNA and soluble TNF-α (sTNF-α) protein, and increased apoptosis (phosphatidyl serine exposure on the outer cell membrane and nuclear condensation). Stable RNA interference-mediated RBM10 knockdown clones were less susceptible to TNF-α-mediated apoptosis, and had decreased sTNF-α protein levels. Elevated levels of TNF-α associated with RBM10 overexpression resulted from increased TNF-α transcription, not TNF-α mRNA stabilization. These results suggest that RBM10 has the ability to modulate apoptosis, and that it does so via a mechanism involving alterations to TNFR super family-mediated signaling. These data provide the first direct evidence that human RBM10 can function as an apoptosis modulator and cytokine expression regulator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.