ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2016
Lifestyle Factors and Risk of Restless Legs Syndrome: Prospective Cohort Study.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The global and regional prevalence of restless legs syndrome among adults: A systematic review and modelling analysis.Journal of global health · 2024Pooled it
- Large genome-wide association study identifies three novel risk variants for restless legs syndrome.Communications biology · 2020Pooled it
- Development of a Stepped-Care Pathway for Managing Willis-Ekbom Disease/Restless Legs Syndrome During Pregnancy: A Best Evidence Synthesis.Nature and science of sleep · 2026Article
- Article
- Prerequisites for self-care actions in individuals with restless legs syndrome-A deductive qualitative analysis based on the COM-B model.Journal of health psychology · 2025Article
- Caffeine in Aging Brains: Cognitive Enhancement, Neurodegeneration, and Emerging Concerns About Addiction.International journal of environmental research and public health · 2025Review
- Machine learning-based prediction of restless legs syndrome using digital phenotypes from wearables and smartphone data.Scientific reports · 2025Article
- Association of restless legs syndrome and obesity: A sub-population of the MASHAD cohort study.Neurobiology of sleep and circadian rhythms · 2025Article
- Characteristics of the differential response to exercise in adults with restless legs syndrome.Sleep medicine · 2025Article
- Sarcopenia Seems to Be Common in Older Patients With Restless Legs Syndrome.Journal of cachexia, sarcopenia and muscle · 2025Article
- Stroke-related restless leg syndrome in hemorrhagic and ischemic stroke patients.SAGE open medicine · 2025Article
- Association of lifestyle with sleep health in general population in China: a cross-sectional study.Translational psychiatry · 2024Article
- Article
- Sleep pattern and disorders among pregnant women in Ibadan, Southwest Nigeria.BMC women's health · 2024Article
- Correlates of Restless Legs Syndrome in Older People.Journal of clinical medicine · 2024Article
- Body mass index and sleep disturbances: a systematic review and meta-analysis.Postepy psychiatrii neurologii · 2023Review
- The Obesity-Related Dietary Pattern Is Associated with Higher Risk of Sleep Disorders: A Cross-Sectional Study from NHANES.Nutrients · 2022Article
- Chronic inflammation markers and cytokine-specific autoantibodies in Danish blood donors with restless legs syndrome.Scientific reports · 2022Article
- The prevalence of and risk factors for restless legs syndrome: A nationwide study.Frontiers in psychiatry · 2022Article
- Disruptive Behaviors and Intellectual Disability: Creating a New Script.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
STUDY
objectivesTo examine the association between modifiable lifestyle factors, and the risk of developing restless legs syndrome (RLS).
methodsThis is a Prospective Cohort study of population including 12,812 men participating in Health Professionals Follow-up Study and 42,728 women participating in the Nurses' Health study II. The participants were free of RLS at baseline (2002 for the HPFS and 2005 for the NHS II) and free of diabetes and arthritis through follow-up. RLS was assessed via a set of questions recommended by International Restless Legs Syndrome Study group. The Information was collected on height, weight, level of physical activity, dietary intake, and smoking status via questionnaires.
resultsDuring 4-6 years of follow-up, we identified 1,538 incident RLS cases. Participants with normal weight, and who were physically active, non-smoker, and had some alcohol consumption had a lower risk of developing RLS. When we combined the effects of these four factors together, we observed a dose response relationship between the increased number of healthy lifestyle factors and a low risk of RLS: after adjusting for potential confounders the pooled odds ratio was 0.67 (95% CI: 0.47-0.97) for 4 vs.0 healthy factors (p trend < 0.001). In contrast, we did not observe significant associations between caffeine consumption or diet quality as assessed by the Alternate Healthy Eating Index, and altered RLS risk in men and women.
conclusionsSeveral modifiable lifestyle factors may play an important role in RLS risk.
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