Evidence map›Paper›PMID 26446164›Full record

SynthesisBMJ open2015

Prevalence and outcomes of multimorbidity in South Asia: a systematic review.

Sanghamitra Pati, Subhashisa Swain, Mohammad Akhtar Hussain, Marjan van den Akker, Job Metsemakers, J André Knottnerus, Chris Salisbury

Abstract readSystematic Review
In one paragraph

Synthesis in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Determinants of multimorbidity in low- and middle-income countries: A systematic review of longitudinal studies and discovery of evidence gaps.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024
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  13. Multimorbidity in dementia: Current perspectives and future challenges.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sanghamitra PatiIndian Institute of Public Health, Bhubaneswar, Public Health Foundation of India, Bhubaneswar, Odisha, India.
Subhashisa SwainIndian Institute of Public Health, Bhubaneswar, Public Health Foundation of India, Bhubaneswar, Odisha, India.
Mohammad Akhtar HussainDivision of Epidemiology and Biostatistics, School of Public Health, University of Queensland, Brisbane, Queensland, Australia.
Marjan van den AkkerDepartment of Family Medicine, School CAPHRI, Maastricht University, Maastricht, The Netherlands Department of General Practice, KU Leuven, Leuven, Belgium.
Job MetsemakersDepartment of Family Medicine, School CAPHRI, Maastricht University, Maastricht, The Netherlands.
J André KnottnerusDepartment of Family Medicine, School CAPHRI, Maastricht University, Maastricht, The Netherlands.
Chris SalisburyCentre for Academic Primary Care, School of Social and Community Medicine, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-4378-3960

Funding

Wellcome Trust
6 · The paper itself

Abstract

objectiveTo systematically review the studies of prevalence, patterns and consequences of multimorbidity reported from South Asia.

designSystematic review.

settingSouth Asia. DATA SOURCES: Articles were retrieved from two electronic databases (PubMed and Embase) and from the relevant references lists. Methodical data extraction according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines was followed. English-language studies published between 2000 and March 2015 were included. ELIGIBILITY CRITERIA: Studies addressing prevalence, consequences and patterns of multimorbidity in South Asia. Articles documenting presence of two or more chronic conditions were included in the review. The quality and risk of bias were assessed using STROBE criteria. DATA SELECTION: Two reviewers independently assessed studies for eligibility, extracted data and assessed study quality. Due to heterogeneity in methodologies among reported studies, only narrative synthesis of the results was carried out.

resultsOf 11,132, 61 abstracts were selected and 13 were included for final data synthesis. The number of health conditions analysed per study varied from 7 to 22, with prevalence of multimorbidity from 4.5% to 83%. The leading chronic conditions were hypertension, arthritis, diabetes, cardiac problems and skin diseases. The most frequently reported outcomes were increased healthcare utilisation, lowered physical functioning and quality of life, and psychological distress.

conclusionsOur study, a comprehensive mapping of multimorbidity research in South Asia, reveals the insufficient volume of work carried out in this domain. The published studies are inadequate to provide an indication of the magnitude of multimorbidity in these countries. Research into clinical and epidemiological aspects of multimorbidity is warranted to build up scientific evidence in this geographic region. The wide heterogeneity observed in the present review calls for greater methodological rigour while conducting these epidemiological studies. TRIAL REGISTRATION NUMBER: CRD42013005456.

Indexed as

AsiaChronic DiseaseComorbidityHumansPrevalenceQuality of LifePRIMARY CAREPUBLIC HEALTH

Identifiers

PMID26446164
PMCPMC4606435

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.