ArticleNeuroradiology2016
Detection of changes in the periaqueductal gray matter of patients with episodic migraine using quantitative diffusion kurtosis imaging: preliminary findings.
Article in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Microstructural white matter alterations associated with migraine headaches: a systematic review of diffusion tensor imaging studies.Brain imaging and behavior · 2022Pooled it
- Headache-related circuits and high frequencies evaluated by EEG, MRI, PET as potential biomarkers to differentiate chronic and episodic migraine: Evidence from a systematic review.The journal of headache and pain · 2022Pooled it
- Cerebral diffusion kurtosis imaging to assess the pathophysiology of postpartum depression.Scientific reports · 2020Trial
- Alterations of White Matter Microstructure in Migraine Patients Vary in the Peri-ictal Phases.eNeuro · 2025Article
- Impact of truncating diffusion MRI scans on diffusional kurtosis imaging.Magma (New York, N.Y.) · 2024Article
- Contralateral acupuncture for migraine without aura: a randomized trial protocol with multimodal MRI.Frontiers in neuroscience · 2024Article
- Viability of AMURA biomarkers from single-shell diffusion MRI in clinical studies.Frontiers in neuroscience · 2023Article
- Overexpression of BDNF in the ventrolateral periaqueductal gray regulates the behavior of epilepsy-migraine comorbid rats.Brain and behavior · 2022Article
- Toward more robust and reproducible diffusion kurtosis imaging.Magnetic resonance in medicine · 2021Article
- Decreased Resting-State Functional Connectivity of Periaqueductal Gray in Temporal Lobe Epilepsy Comorbid With Migraine.Frontiers in neurology · 2021Article
- Detection of microstructural white matter alterations in functional gastrointestinal disorders assessed by diffusion kurtosis imaging.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- White matter changes in chronic and episodic migraine: a diffusion tensor imaging study.The journal of headache and pain · 2020Observational
- Decreased Mean Kurtosis in the Putamen is a Diagnostic Feature of Minimal Hepatic Encephalopathy in Patients with Cirrhosis.Internal medicine (Tokyo, Japan) · 2019Article
- Volume gain of periaqueductal gray in medication-overuse headache.The journal of headache and pain · 2017Article
- Disrupted functional connectivity of periaqueductal gray subregions in episodic migraine.The journal of headache and pain · 2017Article
- Alteration of gray matter texture features over the whole brain in medication-overuse headache using a 3-dimentional texture analysis.The journal of headache and pain · 2017Article
- Differential diagnosis of parkinsonism by a combined use of diffusion kurtosis imaging and quantitative susceptibility mapping.Neuroradiology · 2017Observational
- Disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache.Scientific reports · 2017Article
- Nonspecific periaqueductal gray lesions on T2WI in episodic migraine.The journal of headache and pain · 2016Article
- Relation between injury of the periaqueductal gray and central pain in patients with mild traumatic brain injury: Observational study.Medicine · 2016Observational
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe periaqueductal gray matter (PAG) is considered to play an important role in generating migraine, but findings from imaging studies remain unclear. Therefore, we investigated whether diffusion kurtosis imaging (DKI) can detect changes in the PAG of migraine patients.
methodsWe obtained source images for DKI from 20 patients with episodic migraine and 20 healthy controls using a 3 T magnetic resonance imaging scanner. Mean kurtosis (MK), fractional anisotropy (FA), and mean diffusivity (MD) maps were generated, and the values of the PAG and other deep gray and white matter structures were automatically measured using an atlas-based region-of-interest analysis. The metrics of these structures were compared between the patients and controls.
resultsThe MK and MD values of the PAG were significantly increased in the migraine patients compared with the controls (p < 0.05). The FA values were not significantly different. There were no significant differences in the metrics of the other structures between the patients and controls. The MK values of the PAG were significantly positively correlated with both age and the untreated period in the patient group under univariate analysis (r = 0.53 and 0.56, respectively; p < 0.05) but not multivariate analysis.
conclusionsDKI detected significant increases in the MK and MD values of the PAG in patients with migraine, which suggests that structural changes in the PAG are associated with the pathophysiological mechanisms of migraine.
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