Evidence map›Paper›PMID 26446126›Full record

ArticleSleep2016

Brain Damage and Motor Cortex Impairment in Chronic Obstructive Pulmonary Disease: Implication of Nonrapid Eye Movement Sleep Desaturation.

Francois Alexandre, Nelly Heraud, Anthony M J Sanchez, Emilie Tremey, Nicolas Oliver, Philippe Guerin, Alain Varray

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01679782 (Phase 1 Impact of Nocturnal Desaturations on Central Motor Drive in COPD Patients), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01679782 completednot on this map

Phase 1 Impact of Nocturnal Desaturations on Central Motor Drive in COPD Patients: A New Insight on the Systemic Effects of the Disease.

TypeobservationalSponsor5 SantéRan2012 to 2014Enrolled137ConditionsChronic Obstructive Pulmonary Disease
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Francois AlexandreMovement To Health Laboratory, Euromov, University of Montpellier, Montpellier, France.
Nelly HeraudClinique du Souffle La Vallonie, Fontalvie, Lodève, France.
Anthony M J SanchezUMR866 Dynamique Musculaire et Métabolisme, INRA, University of Montpellier, Montpellier, France.
Emilie TremeyClinique du Souffle La Vallonie, Fontalvie, Lodève, France.
Nicolas OliverClinique du Souffle La Vallonie, Fontalvie, Lodève, France.
Philippe GuerinClinique du Souffle Les Clarines, Fontalvie, Riom-es-Montagnes, France.
Alain VarrayMovement To Health Laboratory, Euromov, University of Montpellier, Montpellier, France.
Centre hospitalier de Rouffach · FRUniversité de Montpellier · FRHôpital Fontmaure · FRUniversité de Perpignan · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesNonrapid eye movement (NREM) sleep desaturation may cause neuronal damage due to the withdrawal of cerebrovascular reactivity. The current study (1) assessed the prevalence of NREM sleep desaturation in nonhypoxemic patients with chronic obstructive pulmonary disease (COPD) and (2) compared a biological marker of cerebral lesion and neuromuscular function in patients with and without NREM sleep desaturation.

methodsOne hundred fifteen patients with COPD (Global Initiative for Chronic Obstructive Lung Disease [GOLD] grades 2 and 3), resting PaO2 of 60-80 mmHg, aged between 40 and 80 y, and without sleep apnea (apnea-hypopnea index < 15) had polysomnographic sleep recordings. In addition, twenty-nine patients (substudy) were assessed i) for brain impairment by serum S100B (biological marker of cerebral lesion), and ii) for neuromuscular function via motor cortex activation and excitability and maximal voluntary quadriceps strength measurement.

resultsA total of 51.3% patients (n = 59) had NREM sleep desaturation (NREMDes). Serum S100B was higher in the NREMDes patients of the substudy (n = 14): 45.1 [Q1: 37.7, Q3: 62.8] versus 32.9 [Q1: 25.7, Q3: 39.5] pg.ml(-1) (P = 0.028). Motor cortex activation and excitability were lower in NREMDes patients (both P = 0.03), but muscle strength was comparable between groups (P = 0.58).

conclusionsOver half the nonhypoxemic COPD patients exhibited NREM sleep desaturation associated with higher values of the cerebral lesion biomarker and lower neural drive reaching the quadriceps during maximal voluntary contraction. The lack of muscle strength differences between groups suggests a compensatory mechanism(s). Altogether, the results are consistent with an involvement of NREM sleep desaturation in COPD brain impairment. CLINICAL

trial registrationThe study was registered at www.clinicaltrials.gov as NCT01679782.

Indexed as

AdultAgedAged, 80 and overBiomarkersBrain InjuriesFemaleHumansMaleMiddle AgedMotor CortexMuscle ContractionMuscle StrengthOxygenPolysomnographyPrevalencePulmonary Disease, Chronic ObstructiveBiomarkersOxygenS100B protein, humanS100 Calcium Binding Protein beta Subunitcentral nervous systemcerebral cortexelectromyographymuscle weaknessvoluntary activation

Identifiers

PMID26446126
PMCPMC4712404
OpenAlexW2397108897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.