ArticleSleep2016
Perinatal Risk Factors Associated with the Obstructive Sleep Apnea Syndrome in School-Aged Children Born Preterm.
Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Worldwide prevalence and associated risk factors of obstructive sleep apnea: a meta-analysis and meta-regression.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- Sleep and prematurity: sleep outcomes in preterm children and influencing factors.World journal of pediatrics : WJP · 2019Pooled it
- Prevalence and Risk Factors of Sleep Disordered Breathing in School-Aged Children with Bronchopulmonary Dysplasia.Pediatric allergy, immunology, and pulmonology · 2026Article
- Sleep-disordered breathing in a multiethnic cohort of preterm adolescents and adults: assessment of neonatal and subsequent risk factors.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Prevalence of symptoms suggestive of sleep apnea among children and its impact on academic performance.The Journal of the Egyptian Public Health Association · 2025Article
- Flexible bronchoscopy in preterm infants with bronchopulmonary dysplasia: findings and complications in a matched control study.European journal of pediatrics · 2024Article
- Apnea of Prematurity and Oxidative Stress: Potential Implications.Antioxidants (Basel, Switzerland) · 2024Review
- Maternal early pregnancy body mass index and risk of sleep apnea in the offspring.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- [The relationship between birth weight and obstructive sleep apnea in children].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- Infants hospitalized with lower respiratory tract infections during the first two years of life have increased risk of pediatric obstructive sleep apnea.Pediatric pulmonology · 2024Article
- Associations of early life and childhood risk factors with obstructive sleep apnoea in middle-age.Respirology (Carlton, Vic.) · 2024Article
- What do we know about the sleep effects of caffeine used to treat apnoea of prematurity? A systematic review of the literature.Molecular and cellular pediatrics · 2023Review
- Pediatric Sleep Respiratory Disorders: A Narrative Review of Epidemiology and Risk Factors.Children (Basel, Switzerland) · 2023Review
- Sleep-Related Breathing Disorders in Children-Red Flags in Pediatric Care.Journal of clinical medicine · 2022Article
- The Impact of Preterm Birth on Sleep through Infancy, Childhood and Adolescence and Its Implications.Children (Basel, Switzerland) · 2022Review
- Analysis of the Risk Factors Associated With Obstructive Sleep Apnea Syndrome in Chinese Children.Frontiers in pediatrics · 2022Article
- Increased Prostaglandin E2 in Brainstem Respiratory Centers Is Associated With Inhibition of Breathing Movements in Fetal Sheep Exposed to Progressive Systemic Inflammation.Frontiers in physiology · 2022Article
- Article
- Chorioamnionitis, Inflammation and Neonatal Apnea: Effects on Preterm Neonatal Brainstem and on Peripheral Airways: Chorioamnionitis and Neonatal Respiratory Functions.Children (Basel, Switzerland) · 2021Review
- Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
STUDY
objectivesThe obstructive sleep apnea syndrome (OSAS) is more prevalent in ex-preterm children compared to the general pediatric population. However, it is unknown whether OSAS in ex-preterm children is associated with specific perinatal risk factors. This multicenter cohort study aimed to determine perinatal factors associated with OSAS at school age.
methods197 ex-preterm (500-1,250 g) children aged 5-12 y who participated as neonates in a double-blind, randomized clinical trial of caffeine versus placebo (Caffeine for Apnea of Prematurity) underwent comprehensive ambulatory polysomnography. A negative binomial regression model was used to identify perinatal risk factors associated with OSAS.
results19 children had OSAS (9.6%). Chorioamnionitis and multiple gestation were positively associated with OSAS with P values of 0.014 and 0.03, respectively. Maternal white race (P = 0.047) and maternal age (P = 0.002) were negatively associated with OSAS. Other risk factors, such as birth weight, Apgar score at 5 min, antenatal corticosteroids, delivery route, and sex were not significant.
conclusionsOSAS is very frequent, and is associated with chorioamnionitis and multiple gestation in ex-preterm children. Those born to older white mothers appear to be protected. We speculate that the former may be due to systemic inflammation and the latter to a higher socio-economic status. COMMENTARY: A commentary on this article appears in this issue on page 721.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.