Evidence map›Paper›PMID 26446095›Full record

ArticleEuropean journal of nutrition2017

Anti-inflammatory γ- and δ-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats.

Weng-Yew Wong, Leigh C Ward, Chee Wai Fong, Wei Ney Yap, Lindsay Brown

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Article in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Weng-Yew WongSchool of Biomedical Sciences, University of Queensland, Brisbane, QLD, 4072, Australia.
Leigh C WardSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, 4072, Australia.
Chee Wai FongDavos Life Science Pte Ltd, 3 Biopolis Drive, #04-19 Synapse, Singapore, 138623, Singapore.
Wei Ney YapDavos Life Science Pte Ltd, 3 Biopolis Drive, #04-19 Synapse, Singapore, 138623, Singapore.
Lindsay BrownSchool of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD, 4350, Australia. Lindsay.Brown@usq.edu.au.
University of Queensland · AUUniversity of Southern Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study tested the hypothesis that γ- and δ-tocotrienols are more effective than α-tocotrienol and α-tocopherol in attenuating the signs of diet-induced metabolic syndrome in rats.

methodsFive groups of rats were fed a corn starch-rich (C) diet containing 68 % carbohydrates as polysaccharides, while the other five groups were fed a diet (H) high in simple carbohydrates (fructose and sucrose in food, 25 % fructose in drinking water, total 68 %) and fats (beef tallow, total 24 %) for 16 weeks. Separate groups from each diet were supplemented with either α-, γ-, δ-tocotrienol or α-tocopherol (85 mg/kg/day) for the final 8 of the 16 weeks.

resultsH rats developed visceral obesity, hypertension, insulin resistance, cardiovascular remodelling and fatty liver. α-Tocopherol, α-, γ- and δ-tocotrienols reduced collagen deposition and inflammatory cell infiltration in the heart. Only γ- and δ-tocotrienols improved cardiovascular function and normalised systolic blood pressure compared to H rats. Further, δ-tocotrienol improved glucose tolerance, insulin sensitivity, lipid profile and abdominal adiposity. In the liver, these interventions reduced lipid accumulation, inflammatory infiltrates and plasma liver enzyme activities. Tocotrienols were measured in heart, liver and adipose tissue showing that chronic oral dosage delivered tocotrienols to these organs despite low or no detection of tocotrienols in plasma.

conclusionIn rats, δ-tocotrienol improved inflammation, heart structure and function, and liver structure and function, while γ-tocotrienol produced more modest improvements, with minimal changes with α-tocotrienol and α-tocopherol. The most important mechanism of action is likely to be reduction in organ inflammation.

Indexed as

Adipose Tissuealpha-TocopherolAnimalsAnti-Inflammatory AgentsBody CompositionCardiovascular SystemDietary CarbohydratesDiet, High-FatFatty LiverInsulin ResistanceLiverMaleMetabolic SyndromeObesity, AbdominalOrgan SizeRatsalpha-TocopherolAnti-Inflammatory AgentsDietary Carbohydratestocotrienol, alphatocotrienol, deltaTocotrienolsVitamin EAnti-inflammatoryCardiovascularMetabolic syndromeObesityTocopherolsTocotrienols

Identifiers

PMID26446095
OpenAlexW1941461807

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.