Evidence map›Paper›PMID 26446042›Full record

ArticleEvidence-based mental health2015

Meta-analysis of diagnostic accuracy studies in mental health.

Yemisi Takwoingi, Richard D Riley, Jonathan J Deeks

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based mental health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 27 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 27 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 27 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Investigation of the diagnostic performance of the SARS-CoV-2 saliva antigen test: A meta-analysis.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2022
    Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Electrical conductance for the detection of dental caries.The Cochrane database of systematic reviews · 2021
    Pooled it
  19. Pooled it
  20. Fluorescence devices for the detection of dental caries.The Cochrane database of systematic reviews · 2020
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yemisi TakwoingiPublic Health, Epidemiology and Biostatistics, University of Birmingham, Birmingham, UK.
Richard D RileyResearch Institute for Primary Care and Health Sciences, Keele University, Staffordshire, UK.
Jonathan J DeeksPublic Health, Epidemiology and Biostatistics, University of Birmingham, Birmingham, UK.

Funding

Department of Health DRF-2011-04-135Medical Research Council MR/J013595/1Medical Research Council MR/J013595/2
6 · The paper itself

Abstract

objectivesTo explain methods for data synthesis of evidence from diagnostic test accuracy (DTA) studies, and to illustrate different types of analyses that may be performed in a DTA systematic review.

methodsWe described properties of meta-analytic methods for quantitative synthesis of evidence. We used a DTA review comparing the accuracy of three screening questionnaires for bipolar disorder to illustrate application of the methods for each type of analysis.

resultsThe discriminatory ability of a test is commonly expressed in terms of sensitivity (proportion of those with the condition who test positive) and specificity (proportion of those without the condition who test negative). There is a trade-off between sensitivity and specificity, as an increasing threshold for defining test positivity will decrease sensitivity and increase specificity. Methods recommended for meta-analysis of DTA studies --such as the bivariate or hierarchical summary receiver operating characteristic (HSROC) model --jointly summarise sensitivity and specificity while taking into account this threshold effect, as well as allowing for between study differences in test performance beyond what would be expected by chance. The bivariate model focuses on estimation of a summary sensitivity and specificity at a common threshold while the HSROC model focuses on the estimation of a summary curve from studies that have used different thresholds.

conclusionsMeta-analyses of diagnostic accuracy studies can provide answers to important clinical questions. We hope this article will provide clinicians with sufficient understanding of the terminology and methods to aid interpretation of systematic reviews and facilitate better patient care.

Indexed as

Meta-Analysis as TopicPsychological TestsReview Literature as TopicBipolar DisorderHumansMental DisordersResearch DesignSensitivity and SpecificityTerminology as Topic

Identifiers

PMID26446042
PMCPMC4680179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.