Evidence map›Paper›PMID 26445942›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2016

Biological factors and age-dependence of primary motor cortex experimental plasticity.

Renato Polimanti, Ilaria Simonelli, Filippo Zappasodi, Mariacarla Ventriglia, Maria Concetta Pellicciari, Luisa Benussi, Rosanna Squitti, Paolo Maria Rossini, Franca Tecchio

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Serum orexin-A levels are associated with disease progression and motor impairment in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Renato PolimantiDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.
Ilaria SimonelliDepartment of Imaging and Neurodegeneration Laboratory, IRCCS San Raffaele Pisana, Rome, Italy.
Filippo ZappasodiDepartment of Neuroscience, Imaging and Clinical Sciences, University "G. d'Annunzio", Chieti, Italy.
Mariacarla VentrigliaMedical Statistics and Information Technology and Department of Neuroscience, Fatebenefratelli Foundation, AFaR Division, Fatebenefratelli Hospital-Isola Tiberina, Rome, Italy.
Maria Concetta PellicciariCognitive Neuroscience Section and Molecular Markers Laboratory, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Luisa BenussiCognitive Neuroscience Section and Molecular Markers Laboratory, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Rosanna SquittiDepartment of Imaging and Neurodegeneration Laboratory, IRCCS San Raffaele Pisana, Rome, Italy.
Paolo Maria RossiniDepartment of Imaging and Neurodegeneration Laboratory, IRCCS San Raffaele Pisana, Rome, Italy.
Franca TecchioDepartment of Imaging and Neurodegeneration Laboratory, IRCCS San Raffaele Pisana, Rome, Italy. franca.tecchio@cnr.it.
Centro San Giovanni di Dio Fatebenefratelli · ITIstituto di Ricovero e Cura a Carattere Scientifico San RaffaeleFatebenefratelli Hospital · ITNational Research Council · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Chieti-Pescara · ITYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate whether the age-dependence of brain plasticity correlates with the levels of proteins involved in hormone and brain functions we executed a paired associative stimulation (PAS) protocol and blood tests. We measured the PAS-induced plasticity in the primary motor cortex. Blood levels of the brain-derived neurotrophic factor (BDNF), estradiol, the insulin-like growth factor (IGF)-1, the insulin-like growth factor binding protein (IGFBP)-3, progesterone, sex hormone-binding globulin (SHBG), testosterone, and the transforming growth factor beta 1 (TGF-β1) were determined in 15 healthy men and 20 healthy women. We observed an age-related reduction of PAS-induced plasticity in females that it is not present in males. In females, PAS-induced plasticity displayed a correlation with testosterone (p = 0.006) that became a trend after the adjustment for the age effect (p = 0.078). In males, IGF-1 showed a nominally significant correlation with the PAS-induced plasticity (p = 0.043). In conclusion, we observed that hormone blood levels (testosterone in females and IGF-1 in males) may be involved in the age-dependence of brain plasticity.

Indexed as

AgingNeuronal PlasticityAge FactorsBrain-Derived Neurotrophic FactorElectric StimulationEstradiolEvoked Potentials, MotorFemaleHandHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMaleMedian NerveMotor CortexMuscle, SkeletalBDNF protein, humanBrain-Derived Neurotrophic FactorEstradiolIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor ISex Hormone-Binding GlobulinTestosteroneTransforming Growth Factor beta1HormonesInsulin-like growth factor 1Paired associative stimulationPrimary motor cortex plasticitySex differencesTestosterone

Identifiers

PMID26445942
OpenAlexW2119289909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.