Evidence map›Paper›PMID 26445898›Full record

ArticleHead & neck2016

Maintaining physical activity during head and neck cancer treatment: Results of a pilot controlled trial.

Shuang G Zhao, Neil B Alexander, Zora Djuric, Jessica Zhou, Yebin Tao, Matthew Schipper, Felix Y Feng, Avraham Eisbruch, Francis P Worden, Scott J Strath and 1 more

Abstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Predictors of survival among head and neck cancer patients after radiotherapy based on health-related quality of life indices and symptoms-specific outcomes: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Pooled it
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  3. Non-pharmacological interventions targeting mobility among people with advanced cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  4. Pooled it
  5. Effect of exercise across the head and neck cancer continuum: a systematic review of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
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  8. Efficacy of resistance training during adjuvant chemotherapy and radiation therapy in cancer care: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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  15. Feasibility of a comprehensive supervised exercise program during and after treatment of head and neck cancer: a mixed-methods study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shuang G ZhaoDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
Neil B AlexanderDivision of Geriatric and Palliative Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Zora DjuricDepartment of Family Medicine, University of Michigan, Ann Arbor, Michigan.
Jessica ZhouDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
Yebin TaoDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan.
Matthew SchipperDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
Felix Y FengDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
Avraham EisbruchDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
Francis P WordenDivision of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Scott J StrathDepartment of Kinesiology, Center for Aging and Translational Research, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
Shruti JollyDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lona Mody, RAYMOND L YUNG · 2004 to 2026
$29.2M
NCI NIH HHS P30 CA046592NIA NIH HHS P30 AG024824
6 · The paper itself

Abstract

backgroundConcurrent chemoradiotherapy (concurrent CRT) to treat head and neck cancer is associated with significant reductions of weight, mobility, and quality of life (QOL). An intervention focusing on functional exercise may attenuate these losses.

methodsWe allocated patients to a 14-week functional resistance and walking program designed to maintain physical activity during cancer treatment (MPACT group; n = 11), or to usual care (control group; n = 9). Outcomes were assessed at baseline, and 7 and 14 weeks.

resultsCompared to controls, the MPACT participants had attenuated decline or improvement in several strength, mobility, physical activity, diet, and QOL endpoints. These trends were statistically significant (p < .05) in knee strength, mental health, head and neck QOL, and barriers to exercise.

conclusionIn this pilot study of patients with head and neck cancer undergoing concurrent CRT, MPACT training was feasible and maintained or improved function and QOL, thereby providing the basis for larger future interventions with longer follow-up. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1086-E1096, 2016.

Indexed as

ExerciseQuality of LifeChemoradiotherapyFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedPilot ProjectsResistance TrainingWalkingfunctional mobilityhead and neck cancerphysical activityquality of liferadiation therapy

Identifiers

PMID26445898
PMCPMC5304917

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.