ArticleBiomedical engineering online2015
Pulsed 980 nm short wavelength infrared neural stimulation in cochlea and laser parameter effects on auditory response characteristics.
Article in Biomedical engineering online, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Acoustic and optoacoustic stimulations in auditory brainstem response test in salicylate induced tinnitus.Scientific reports · 2023Article
- In-vitro quantitative measurement and analysis of the photosensitivity of cells to a weak pulse laser.Biomedical optics express · 2023Article
- Inhibitory effect of 980-nm laser on neural activity of the rat's cochlear nucleus.Neurophotonics · 2019Article
- Short-wavelength infrared laser activates the auditory neurons: comparing the effect of 980 vs. 810 nm wavelength.Lasers in medical science · 2017Article
- Effect of shorter pulse duration in cochlear neural activation with an 810-nm near-infrared laser.Lasers in medical science · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundAuditory neural stimulation with pulsed infrared radiation has been proposed as an alternative method to activate the auditory nerves in vivo. Infrared wavelengths from 1800-2150 nm with high water absorption were mainly selected in previous studies. However, few researchers have used the short-wavelength infrared (SWIR) for auditory nerve stimulation and limited pulse parameters variability has been investigated so far.
methodsIn this paper, we pioneered to use the 980 nm SWIR laser with adjustable pulse parameter as a stimulus to act on the deafened guinea pigs' cochlea in vivo. Pulsed laser light was guided through the cochlear round window to irradiate the spiral ganglion cells via a 105 μm optical fiber, and then the laser pulse parameters variability and its influence to auditory response characteristics were studied.
resultsThe results showed that the optically evoked auditory brainstem response (OABR) had a similar waveform to the acoustically induced ABR with click sound stimulus. And the evoked OABR amplitude had a positive correlation, while the OABR latency period showed a negative correlation, with the laser pulse energy increase. However, when holding the laser peak power constant, the pulse width variability ranged from 100 to 800 μs showed little influence on the evoked OABR amplitude and its latency period.
conclusionsOur study suggests that 980 nm SWIR laser is an effective stimulus for auditory neurons activation in vivo. The evoked OABR amplitude and latency are highly affected by the laser pulse energy, while not sensitive to the pulse width variability in 100-800 μs range.
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