ArticleCardiovascular diabetology2015
High visceral fat with low subcutaneous fat accumulation as a determinant of atherosclerosis in patients with type 2 diabetes.
Article in Cardiovascular diabetology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The association between the visceral to subcutaneous abdominal fat ratio and the risk of cardiovascular diseases: a systematic review.BMC public health · 2024Pooled it
- Pooled it
- Role of systemic and epicardial adipose tissue in cardiometabolic disease.Nature reviews. Cardiology · 2026Review
- Deep Learning-Derived Body Composition Analysis Predicts Long-Term Mortality After Transcatheter Aortic Valve Replacement.Mayo Clinic proceedings. Digital health · 2026Article
- Hybrid imaging-clinical model for predicting microvascular invasion in hepatocellular carcinoma using deep learning-derived features from CT.Physical and engineering sciences in medicine · 2026Article
- Visceral fat area as a predictor for macrovascular complications in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
- Association analysis of obesity and hypertension and research on ethnic heterogeneity: a cross-sectional study based on different populations in Northwest China.BMC public health · 2025Article
- Article
- Joint analysis of atherogenic index of plasma clusters and a body shape index trajectories in incident stroke risk.Lipids in health and disease · 2025Article
- Modification of adipose mass by targeting distal enhancers of Ptrf.BMC biology · 2025Article
- Impact of visceral fat area on surgical difficulty during robotic distal pancreatectomy (TAKUMI-2).Surgical endoscopy · 2025Article
- Nonlinear Association Between the Visceral-to-Subcutaneous Fat Area Ratio and the Risk of Hypertension in Prediabetic Individuals: Evidence From a Large-Scale Health Screening Dataset in China.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Exploring the link between visceral fat and cardiovascular disease in type 2 diabetes: evidence from ct measurements.Frontiers in endocrinology · 2025Article
- Association of weight-adjusted waist index with preserved ratio impaired spirometry and all-cause mortality.Frontiers in nutrition · 2025Article
- U-Shaped Association of Visceral Fat Area With Diabetic Peripheral Neuropathy.Journal of diabetes research · 2025Article
- Association Between Weight-Adjusted Waist Index and Emphysema in Adults in the United States: A Cross-Sectional Study Involving 44,949 Participants.Advances in respiratory medicine · 2024Article
- Coexistence of high visceral fat area and sarcopenia is associated with atherosclerotic markers in old-old patients with diabetes: A cross-sectional study.Journal of diabetes investigation · 2024Article
- Modern Management of Cardiometabolic Continuum: From Overweight/Obesity to Prediabetes/Type 2 Diabetes Mellitus. Recommendations from the Eastern and Southern Europe Diabetes and Obesity Expert Group.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Review
- Visceral fat area is more strongly associated with arterial stiffness than abdominal subcutaneous fat area in Chinese patients with type 2 diabetes.Diabetology & metabolic syndrome · 2024Article
- Differences in Anthropometric Measures Based on Sex, Age, and Health Status: Findings From the German National Cohort (NAKO).Deutsches Arzteblatt international · 2024Observational
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14 authors.
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Abstract
backgroundAbdominal visceral obesity has been reported to be associated with cardiovascular risks than body mass index, waist circumference, and abdominal subcutaneous fat. On the other hand, there is evidence that subcutaneous fat has a beneficial role against cardio-metabolic risks such as diabetes or dyslipidemia. However, little is known regarding the association between high visceral fat with low subcutaneous fat accumulation and the risk for atherosclerosis.
methodsThis study was designed to elucidate whether high visceral fat with low subcutaneous fat accumulation enhances the risk for atherosclerosis in patients with type 2 diabetes. This is a cross-sectional study of 148 patients with type 2 diabetes (mean age 65 ± 12 years; 44.5% female). Visceral fat area (VFA, cm(2)) and subcutaneous fat area (SFA, cm(2)) were assessed by abdominal computed tomography. Carotid intima media thickness (CIMT, mm) measured by ultrasonography was used for the assessment of atherosclerosis. Patients were divided into four groups: SFA < 100 cm(2) and VFA < 100 cm(2) [S(-)V(-)], SFA ≥ 100 cm(2) and VFA < 100 cm(2) [S(+)V(-)], SFA < 100 cm(2) and VFA ≥ 100 cm(2) [S(-)V(+)], and SFA ≥ 100 cm(2) and VFA ≥ 100 cm(2) [S(+)V(+)]. Linear regression analysis with a stepwise procedure was used for the statistical analyses.
resultsAmong the patients examined, 16.3% were S(-)V(+). Mean (95 % confidence interval) of CIMT adjusting for age and gender were 0.80 (0.69-0.91), 0.86 (0.72-1.01), 1.28 (1.11-1.44) and 0.83 (0.77-0.88) in patients with S(-)V(-), S(+)V(-), S(-)V(+) and S(+)V(+), respectively (p < 0.001). The S(-)V(+) patients exhibited significantly older than S(-)V(-) patients and those with S(+)V(+) and had a highest VFA-SFA ratio (V/S ratio) among the four groups. S(-)V(+) patients were male predominant (100% male), and S(+)V(-) patients showed female predominance (82% female). In multivariate linear regression analysis (Adjusted R(2) = 0.549), S(-)V(+) was significantly associated with CIMT (Standardized β 0.423, p < 0.001). Notably, S(+)V(+) was inversely associated with CIMT in the multivariate model.
conclusionsThis study provides evidence that high visceral fat with low subcutaneous fat accumulation is an important determinant of carotid atherosclerosis and high subcutaneous fat could be protective against atherosclerosis in patients with type 2 diabetes.
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