ArticleJournal of neurophysiology2015
Corticotropin-releasing factor increases Purkinje neuron excitability by modulating sodium, potassium, and Ih currents.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- The effects of corticotropin-releasing factor on motor learning.Scientific reports · 2024Article
- Neuropeptides and Their Roles in the Cerebellum.International journal of molecular sciences · 2024Review
- Article
- GLP-1 enhances hyperpolarization-activated currents of mouse cerebellar Purkinje cellFrontiers in molecular neuroscience · 2023Article
- Ethanol withdrawal-induced adaptations in prefrontal corticotropin releasing factor receptor 1-expressing neurons regulate anxiety and conditioned rewarding effects of ethanol.Molecular psychiatry · 2022Article
- ATR regulates neuronal activity by modulating presynaptic firing.Nature communications · 2021Article
- A multi-omic study for uncovering molecular mechanisms associated with hyperammonemia-induced cerebellar function impairment in rats.Cell biology and toxicology · 2021Article
- Adaptive Balance in Posterior Cerebellum.Frontiers in neurology · 2021Review
- Corticotrophin-Releasing Factor Modulates the Facial Stimulation-Evoked Molecular Layer Interneuron-Purkinje Cell Synaptic TransmissionFrontiers in cellular neuroscience · 2020Article
- Cerebellar Learning Properties Are Modulated by the CRF Receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Inferior olive CRF plays a role in motor performance under challenging conditions.Translational psychiatry · 2018Article
- Corticotrophin-Releasing Factor Modulates Cerebellar Purkinje Cells Simple Spike ActivityFrontiers in cellular neuroscience · 2018Article
- Estradiol-Dependent Stimulation and Suppression of Gonadotropin-Releasing Hormone Neuron Firing Activity by Corticotropin-Releasing Hormone in Female Mice.Endocrinology · 2018Article
- Inverse Stochastic Resonance in Cerebellar Purkinje Cells.PLoS computational biology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Corticotropin-releasing factor (CRF) is a neuromodulator closely associated with stress responses. It is synthesized and released in the central nervous system by various neurons, including neurons of the inferior olive. The targets of inferior olivary neurons, the cerebellar Purkinje neurons (PNs), are endowed with CRF receptors. CRF increases the excitability of PNs in vivo, but the biophysical mechanism is not clear. Here we examine the effect of CRF on the firing properties of PNs using acute rat cerebellar slices. CRF increased the PN firing rate, regardless of whether they were firing tonically or switching between firing and quiescent periods. Current- and voltage-clamp experiments showed that the increase in firing rate was associated with a voltage shift of the activation curve of the persistent sodium current and hyperpolarizing-activated current, as well as activation of voltage-dependent potassium current. The multiple effects on various ionic currents, which are in agreement with the possibility that activation of CRF receptors triggers several intracellular pathways, are manifested as an increase excitability of PN.
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