Evidence map›Paper›PMID 26445868›Full record

ArticleJournal of neurophysiology2015

Integrating multiple sensory systems to modulate neural networks controlling posture.

I Lavrov, Y Gerasimenko, J Burdick, H Zhong, R R Roy, V R Edgerton

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

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  16. IpsilesionalBrain communications · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

I LavrovDepartments of Integrative Biology and Physiology and Neurobiology, University of California, Los Angeles, California; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia; and igor.lavrov@gmail.com.
Y GerasimenkoDepartments of Integrative Biology and Physiology and Neurobiology, University of California, Los Angeles, California; Pavlov Institute of Physiology, St. Petersburg, Russia; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia; and.
J BurdickBioengineering, California Institute of Technology, Pasadena, California.
H ZhongDepartments of Integrative Biology and Physiology and Neurobiology, University of California, Los Angeles, California; Brain Research Institute, University of California, Los Angeles, California;
R R RoyDepartments of Integrative Biology and Physiology and Neurobiology, University of California, Los Angeles, California; Brain Research Institute, University of California, Los Angeles, California;
V R EdgertonDepartments of Integrative Biology and Physiology and Neurobiology, University of California, Los Angeles, California; Brain Research Institute, University of California, Los Angeles, California;
University of California, Los Angeles · USCalifornia Institute of Technology · USKazan Federal University · RUPavlov Institute of Physiology of the Russian Academy of Sciences · RU

Funding

Enabling forelimb function with agonist drug and epidural stimulation in SCIU01EB015521 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE, LU, DANIEL · 2013 to 2017
$6.0M
Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCIR01EB007615 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE · 2008 to 2013
$4.9M
NIBIB NIH HHS R01 EB-007615NIBIB NIH HHS U01 EB015521NIBIB NIH HHS U01 EB-15521
6 · The paper itself

Abstract

In this study we investigated the ability of sensory input to produce tonic responses in hindlimb muscles to facilitate standing in adult spinal rats and tested two hypotheses: 1) whether the spinal neural networks below a complete spinal cord transection can produce tonic reactions by activating different sensory inputs and 2) whether facilitation of tonic and rhythmic responses via activation of afferents and with spinal cord stimulation could engage similar neuronal mechanisms. We used a dynamically controlled platform to generate vibration during weight bearing, epidural stimulation (at spinal cord level S1), and/or tail pinching to determine the postural control responses that can be generated by the lumbosacral spinal cord. We observed that a combination of platform displacement, epidural stimulation, and tail pinching produces a cumulative effect that progressively enhances tonic responses in the hindlimbs. Tonic responses produced by epidural stimulation alone during standing were represented mainly by monosynaptic responses, whereas the combination of epidural stimulation and tail pinching during standing or epidural stimulation during stepping on a treadmill facilitated bilaterally both monosynaptic and polysynaptic responses. The results demonstrate that tonic muscle activity after complete spinal cord injury can be facilitated by activation of specific combinations of afferent inputs associated with load-bearing proprioception and cutaneous input in the presence of epidural stimulation and indicate that whether activation of tonic or rhythmic responses is generated depends on the specific combinations of sources and types of afferents activated in the hindlimb muscles.

Indexed as

PostureSensationAnimalsFemaleHindlimbMuscle, SkeletalNerve NetRatsRats, Sprague-DawleySpinal CordSynapseslocomotionpostural controlspinal cord stimulationspinal cord transectionvibration

Identifiers

PMID26445868
PMCPMC4868380
OpenAlexW1907807728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.