ArticlePloS one2015
Modelling Blood Flow and Metabolism in the Preclinical Neonatal Brain during and Following Hypoxic-Ischaemia.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The influence of carbon dioxide on cerebral metabolism and oxygen consumption: combining multimodal monitoring with dynamic systems modelling.Biology open · 2024Article
- Computational analysis of cortical neuronal excitotoxicity in a large animal model of neonatal brain injury.Journal of neurodevelopmental disorders · 2022Article
- Systems Biology Model of Cerebral Oxygen Delivery and Metabolism During Therapeutic Hypothermia: Application to the Piglet Model.Advances in experimental medicine and biology · 2021Article
- Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism.Advances in experimental medicine and biology · 2020Article
- Oxygen dependency of mitochondrial metabolism indicates outcome of newborn brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Observational
- Brain cytochrome-c-oxidase as a marker of mitochondrial function: A pilot study in major depression using NIRS.Depression and anxiety · 2019Article
- A Bayesian framework for the analysis of systems biology models of the brain.PLoS computational biology · 2019Article
- Haemodynamic Instability and Brain Injury in Neonates Exposed to Hypoxia⁻Ischaemia.Brain sciences · 2019Review
- Simultaneous monitoring of cerebral perfusion and cytochrome c oxidase by combining broadband near-infrared spectroscopy and diffuse correlation spectroscopy.Biomedical optics express · 2018Article
- WeBCMD: A cross-platform interface for the BCMD modelling framework.Wellcome open research · 2017Article
- Investigating mitochondrial redox state using NADH and NADPH autofluorescence.Free radical biology & medicine · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Hypoxia-ischaemia (HI) is a major cause of neonatal brain injury, often leading to long-term damage or death. In order to improve understanding and test new treatments, piglets are used as preclinical models for human neonates. We have extended an earlier computational model of piglet cerebral physiology for application to multimodal experimental data recorded during episodes of induced HI. The data include monitoring with near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS), and the model simulates the circulatory and metabolic processes that give rise to the measured signals. Model extensions include simulation of the carotid arterial occlusion used to induce HI, inclusion of cytoplasmic pH, and loss of metabolic function due to cell death. Model behaviour is compared to data from two piglets, one of which recovered following HI while the other did not. Behaviourally-important model parameters are identified via sensitivity analysis, and these are optimised to simulate the experimental data. For the non-recovering piglet, we investigate several state changes that might explain why some MRS and NIRS signals do not return to their baseline values following the HI insult. We discover that the model can explain this failure better when we include, among other factors such as mitochondrial uncoupling and poor cerebral blood flow restoration, the death of around 40% of the brain tissue.
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