Evidence map›Paper›PMID 26445244›Full record

ArticleMagnetic resonance in medicine2016

Spectral improvement by fourier thresholding of in vivo dynamic spectroscopy data.

Benjamin Rowland, Sai K Merugumala, Huijun Liao, Mark A Creager, James Balschi, Alexander P Lin

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Combining hyperpolarizedJournal of applied physiology (Bethesda, Md. : 1985) · 2025
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  5. PCA denoising and Wiener deconvolution ofMagnetic resonance in medicine · 2021
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  6. Whole brainMagnetic resonance in medicine · 2020
    Article
  7. Article
  8. Tai Chi Improves Brain Metabolism and Muscle Energetics in Older Adults.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Benjamin RowlandCenter for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Sai K MerugumalaCenter for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Huijun LiaoCenter for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Mark A CreagerCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
James BalschiCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Alexander P LinCenter for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Funding

Active transmembrane water cycling kinetics: A Cellular Metabolic 1H MR BiomarkerR21EB014414 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI BALSCHI, JAMES ALVIN · 2013 to 2014
$491k
NIBIB NIH HHS R21 EB014414
6 · The paper itself

Abstract

purposeMR spectroscopy (MRS) typically requires averaging of multiple acquisitions to achieve adequate signal-to-noise ratio (SNR). In systems undergoing dynamic changes this can compromise the temporal resolution of the measurement. One such example is (31) P MRS of exercising skeletal muscle. Spectral improvement by Fourier thresholding (SIFT) offers a way of suppressing noise without averaging. In this study, we evaluate the performance of SIFT in healthy subjects and clinical cases.

methods(31) P MRS of the calf or thigh muscle of subjects (n = 12) was measured continuously before, during, and after exercise. The data were processed conventionally and with the addition of SIFT before quantifying peak amplitudes and frequencies. The postexercise increase in the amplitude of phosphocreatine was also characterized by fitting with an exponential function to obtain the recovery time constant.

resultsSubstantial reductions in the uncertainty of peak fitting for phosphocreatine (73%) and inorganic phosphate (60%) were observed when using SIFT relative to conventional processing alone. SIFT also reduced the phosphocreatine recovery time constant uncertainty by 38%.

conclusionSIFT considerably improves SNR, which improved quantification and parameter estimation. It is suitable for any type of time varying MRS and is both straightforward and fast to apply. Magn Reson Med 76:978-985, 2016. © 2015 Wiley Periodicals, Inc.

Indexed as

AlgorithmsFourier AnalysisAdultAgedAged, 80 and overAnimalsCattleEnergy MetabolismHumansMagnetic Resonance SpectroscopyMiddle AgedMuscle, SkeletalPhosphatesPhosphocreatinePhosphorus IsotopesReproducibility of ResultsPhosphatesPhosphocreatinePhosphorus Isotopes31P spectroscopyenergy metabolismexercisephosphocreatinesignal processing

Identifiers

PMID26445244
PMCPMC4824679

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.