Evidence map›Paper›PMID 26445135›Full record

ArticleMagnetic resonance in medicine2016

Evaluation of a three-dimensional MR acoustic radiation force imaging pulse sequence using a novel unbalanced bipolar motion encoding gradient.

Joshua T de Bever, Henrik Odéen, Nick Todd, Alexis I Farrer, Dennis L Parker

Abstract readEvaluation Study
In one paragraph

Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Magnetic Resonance Acoustic Radiation Force Imaging (MR-ARFI).Journal of magnetic resonance imaging : JMRI · 2025
    Review
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joshua T de BeverSchool of Computing, Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, Utah, USA.
Henrik OdéenDepartment of Physics, Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, Utah, USA.
Nick ToddDepartment of Physics, Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, Utah, USA.
Alexis I FarrerDepatment of Bioengineering, Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, Utah, USA.
Dennis L ParkerDepartment of Radiology, Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, Utah, USA.

Funding

Non-Invasive MRI-Guided HIFU for Breast Cancer TherapyR01CA172787 · NCI · UNIVERSITY OF UTAH · PI PARKER, DENNIS L · 2013 to 2017
$2.7M
Improved MRI temperature imaging using a subject-specific biophysical modelR01EB013433 · NIBIB · UNIVERSITY OF UTAH · PI PARKER, DENNIS L · 2011 to 2014
$1.8M
NCI NIH HHS R01 CA172787NIBIB NIH HHS R01 EB013433
6 · The paper itself

Abstract

purposeMR guided focused ultrasound procedures require accurate focal spot localization in three dimensions. This study presents a three-dimensional (3D) pulse sequence for acoustic radiation force imaging (ARFI) that efficiently localizes the focal spot by means of ultrasound induced tissue displacement over a large field-of-view.

methodsA novel unbalanced bipolar motion encoding gradient was implemented to maximize time available for motion encoding, reduce echo times, and allow for longer echo train lengths. Two advanced features, kz reduction factor (KZRF) and kz -level interleaving, were implemented to reduce tissue heating. Studies in gelatin phantoms compared the location of peak displacement and temperature measured by 3D MR thermometry. MR-ARFI induced tissue heating was evaluated through a parametric study of sequence parameters and MR thermometry measurements during repeated application of ARFI sonication patterns. Sequence performance was characterized in the presence of respiration and tissue inhomogeneity.

resultsThe location of peak displacement and temperature rise agreed within 0.2 ± 0.1 mm and 0.5 ± 0.3 mm in the transverse and longitudinal direction, respectively. The 3D displacement maps were acquired safely, and the KZRF and kz -level interleaving features reduced tissue heating by 51%. High quality displacement maps were obtained despite respiration and tissue inhomogeneities.

conclusionThis sequence provides a safe, accurate, and simple approach to localizing the focal spot in three dimensions with a single scan. Magn Reson Med 76:803-813, 2016. © 2015 Wiley Periodicals, Inc.

Indexed as

AlgorithmsSignal Processing, Computer-AssistedCadaverElasticity Imaging TechniquesFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMotionReproducibility of ResultsSensitivity and Specificity3Dacoustic radiation forceARFIfocused ultrasoundMRIthree-dimensional

Identifiers

PMID26445135
PMCPMC5450949

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.