Evidence map›Paper›PMID 26445118›Full record

ArticlePloS one2015

Lower Urinary Tract Symptoms, Depression, Anxiety and Systemic Inflammatory Factors in Men: A Population-Based Cohort Study.

Sean Martin, Andrew Vincent, Anne W Taylor, Evan Atlantis, Alicia Jenkins, Andrzej Januszewski, Peter O'Loughlin, Gary Wittert

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03435991 ('The Experience Sampling Method), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03435991 unknown statusnot on this mapstarted 2018, after this paper: background citation

'The Experience Sampling Method (ESM): a Real-time Patient-Reported Outcome Measure for Symptom Assessment in Patients With Overactive Bladder Syndrome.'

TypeobservationalSponsorMaastricht University Medical CenterRan2018 to 2021Enrolled132ConditionsOveractive Bladder, Overactive Bladder SyndromeArmsValidation Experience Sampling Method 'Uromate'
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

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  13. Coping with the Experience of Bad Sleep and Fatigue Associated with the Nursing Clinical Practicum.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sean MartinFreemasons Foundation Centre for Men's Health, University of Adelaide, Adelaide, South Australia, Australia; School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Andrew VincentFreemasons Foundation Centre for Men's Health, University of Adelaide, Adelaide, South Australia, Australia; School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Anne W TaylorPopulation Research and Outcome Studies, University of Adelaide, Adelaide, South Australia, Australia.
Evan AtlantisSchool of Medicine, University of Adelaide, Adelaide, South Australia, Australia; School of Nursing and Midwifery, University of Western Sydney, Sydney, New South Wales, Australia.
Alicia JenkinsNHMRC Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, Australia.
Andrzej JanuszewskiNHMRC Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, Australia.
Peter O'LoughlinChemical Pathology, SA Pathology, Adelaide, South Australia, Australia.
Gary WittertFreemasons Foundation Centre for Men's Health, University of Adelaide, Adelaide, South Australia, Australia; School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
University of Adelaide · AUUniversity of Sydney · AUSouth Australia Pathology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe relationship between lower urinary tract symptoms (LUTS) and common mental health disorders such as depression and anxiety in men remains unclear. Inflammation has recently been identified as an independent risk factor for LUTS and depression. This study aimed to assess the association between depression, anxiety and LUTS, and the moderating influence of systemic inflammation, in the presence of other biopsychosocial confounders.

methodsParticipants were randomly-selected from urban, community-dwelling males aged 35-80 years at recruitment (n = 1195; sample response rate:67.8%). Of these, 730 men who attended baseline (2002-5) and follow-up clinic visits (2007-10), with complete outcome measures, and without prostate or bladder cancer and/or surgery, neurodegenerative conditions, or antipsychotic medications use, were selected for the present study. Unadjusted and multi-adjusted regression models of incident storage and voiding LUTS and incident depression and anxiety were combined with serum inflammatory markers (high-sensitive C-reactive protein (hsCRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), myeloperoxidase (MPO), soluble e-selectin (e-Sel)) and socio-demographic, lifestyle, and health-related factors. Hierarchical multiple regression was used to assessed the moderating effect of inflammatory markers.

resultsThe incidence of storage, voiding LUTS, depression and anxiety was 16.3% (n = 108), 12.1% (n = 88), 14.5% (n = 108), and 12.2% (n = 107). Regression models demonstrated that men with depression and anxiety at baseline were more likely to have incident storage, but not voiding LUTS (OR: 1.26, 99%CI: 1.01-4.02; and OR:1.74; 99%CI:1.05-2.21, respectively). Men with anxiety and storage LUTS at baseline were more likely to have incident depression (OR: 2.77, 99%CI: 1.65-7.89; and OR:1.45; 99%CI:1.05-2.36, respectively), while men with depression and voiding LUTS were more likely to have anxiety at follow-up (OR: 5.06, 99%CI: 2.81-9.11; and OR:2.40; 99%CI:1.16-4.98, respectively). CRP, TNF-α, and e-Sel were found to have significant moderating effects on the development of storage LUTS (1.06, 0.91-1.96, R2 change: 12.7%), depression (1.17, 1.01-1.54, R2 change: 9.8%), and anxiety (1.35, 1.03-1.76, R2 change: 10.6%), respectively.

conclusionsThere is a bidirectional relationship between storage, but not voiding, LUTS and both depression and anxiety. We observed variable moderation effects for selected inflammatory markers on the development of depression, anxiety and storage LUTS.

Indexed as

AdultAgedAged, 80 and overAnxietyAnxiety DisordersC-Reactive ProteinDepressionDepressive DisorderE-SelectinHumansInflammationInterleukin-6Life StyleLower Urinary Tract SymptomsMaleMiddle AgedC-Reactive ProteinE-SelectinIL6 protein, humanInterleukin-6PeroxidaseTumor Necrosis Factor-alpha

Identifiers

PMID26445118
PMCPMC4622039
OpenAlexW2125926644

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.