Evidence map›Paper›PMID 26445115›Full record

SynthesisThe Journal of clinical endocrinology and metabolism2015

Effect of Parathyroidectomy Upon Left Ventricular Mass in Primary Hyperparathyroidism: A Meta-Analysis.

Donald J McMahon, Angela Carrelli, Nick Palmeri, Chiyuan Zhang, Marco DiTullio, Shonni J Silverberg, Marcella D Walker

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Parathyroidectomy for adults with primary hyperparathyroidism.The Cochrane database of systematic reviews · 2023
    Pooled it
  3. Pooled it
  4. Article
  5. Vitamin D-Parathyroid Hormone-Fibroblast Growth Factor 23 Axis and Cardiac Remodeling.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025
    Review
  6. Article
  7. Observational
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  10. Article
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  12. Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Donald J McMahonDivision of Endocrinology (D.J.M., A.C., C.Z., S.J.S., M.D.W.), Department of Medicine, and Division of Cardiology (M.D.), Department of Medicine, Columbia University, College of Physicians and Surgeons, and Department of Medicine (N.P.), New York Presbyterian/Columbia University Medical Center, New York, New York 10032.
Angela CarrelliDivision of Endocrinology (D.J.M., A.C., C.Z., S.J.S., M.D.W.), Department of Medicine, and Division of Cardiology (M.D.), Department of Medicine, Columbia University, College of Physicians and Surgeons, and Department of Medicine (N.P.), New York Presbyterian/Columbia University Medical Center, New York, New York 10032.
Nick PalmeriDivision of Endocrinology (D.J.M., A.C., C.Z., S.J.S., M.D.W.), Department of Medicine, and Division of Cardiology (M.D.), Department of Medicine, Columbia University, College of Physicians and Surgeons, and Department of Medicine (N.P.), New York Presbyterian/Columbia University Medical Center, New York, New York 10032.
Chiyuan ZhangDivision of Endocrinology (D.J.M., A.C., C.Z., S.J.S., M.D.W.), Department of Medicine, and Division of Cardiology (M.D.), Department of Medicine, Columbia University, College of Physicians and Surgeons, and Department of Medicine (N.P.), New York Presbyterian/Columbia University Medical Center, New York, New York 10032.
Marco DiTullioDivision of Endocrinology (D.J.M., A.C., C.Z., S.J.S., M.D.W.), Department of Medicine, and Division of Cardiology (M.D.), Department of Medicine, Columbia University, College of Physicians and Surgeons, and Department of Medicine (N.P.), New York Presbyterian/Columbia University Medical Center, New York, New York 10032.
Shonni J SilverbergDivision of Endocrinology (D.J.M., A.C., C.Z., S.J.S., M.D.W.), Department of Medicine, and Division of Cardiology (M.D.), Department of Medicine, Columbia University, College of Physicians and Surgeons, and Department of Medicine (N.P.), New York Presbyterian/Columbia University Medical Center, New York, New York 10032.
Marcella D WalkerDivision of Endocrinology (D.J.M., A.C., C.Z., S.J.S., M.D.W.), Department of Medicine, and Division of Cardiology (M.D.), Department of Medicine, Columbia University, College of Physicians and Surgeons, and Department of Medicine (N.P.), New York Presbyterian/Columbia University Medical Center, New York, New York 10032.

Funding

Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Non-Classical Manifestations of Primary HyperparathyroidismK24DK074457 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SILVERBERG, SHONNI J · 2006 to 2016
$1.7M
NCATS NIH HHS UL1 TR000040NIDDK NIH HHS K24 DK074457
6 · The paper itself

Abstract

contextPrimary hyperparathyroidism (PHPT) has been associated with increased left ventricular mass (LVM) in many studies. Most studies have been inadequately powered to assess the effect of parathyroidectomy (PTX) on LVM.

objectiveThe objective was to evaluate whether PTX has a benefit on LVM in patients with PHPT. DATA SOURCES: Sources included PubMed, Medline, Cochrane Library, clinicaltrials.gov, review articles, and abstracts from meetings. STUDY SELECTION: Eligible studies included prospective studies of PTX vs observation or PTX alone in patients with PHPT who had LVM measured by echocardiography. DATA EXTRACTION: Two investigators independently identified eligible studies and extracted data. Random-effects models were used to obtain final pooled estimates. DATA SYNTHESIS: Fifteen studies (four randomized controlled trials and 11 observational) of 457 participants undergoing PTX were included. PTX was associated with a reduction in LVM (crude Hedges gu -0.290 ± 0.070, 95% confidence interval [CI] -0.423 to -0.157) of 11.6 g/m(2) (12.5%) on average. Effect size estimates differed by study duration (P < .001), with improvements seen in shorter (≤ 6 mo) but not longer studies. There was a trend toward greater improvement in observational studies vs randomized controlled trials (P = .07), and both serum calcium and PTH were higher in the former. Using random-effects models, the estimated effect size remained significant (Hedges gu -0.250, 95% CI -0.450 to -0.050). Higher preoperative PTH but not calcium was associated with a greater decline in LVM (β = -.039, 95% CI -0.075 to -0.004).

conclusionPTX reduced LVM in PHPT, and higher preoperative PTH levels were associated with greater improvements. Because the benefit was limited to short-term studies and PHPT disease severity was not independent of study design, further work is needed to clarify the factors that influence the change in LVM and whether the benefit persists beyond 6 months after PTX. Although the clinical significance of the LVM improvement is unclear, these data indicate that PTH may underlie increased LVM in PHPT.

Indexed as

ParathyroidectomyHeart VentriclesHumansHyperparathyroidism, PrimaryHypertrophy, Left VentricularObservational Studies as TopicRandomized Controlled Trials as TopicTreatment Outcome

Identifiers

PMID26445115
PMCPMC4667168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.