Evidence map›Paper›PMID 26445106›Full record

ArticleJournal of hematology & oncology2015

Unrelated cord blood transplantation for adult patients with acute myeloid leukemia: higher incidence of acute graft-versus-host disease and lower survival in male patients transplanted with female unrelated cord blood--a report from Eurocord, the Acute Leukemia Working Party, and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the European Group for Blood and Marrow Transplantation.

Frédéric Baron, Myriam Labopin, Annalisa Ruggeri, Mohamad Mohty, Guillermo Sanz, Noel Milpied, Andrea Bacigalupo, Alessandro Rambaldi, Francesca Bonifazi, Alberto Bosi and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hematology & oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Clinical Advancement and Challenges ofClinical hematology international · 2020
    Review
  6. Role of Stem-Cell Transplantation in Leukemia Treatment.Stem cells and cloning : advances and applications · 2020
    Review
  7. Article
  8. Clinical trials of CAR-T cells in China.Journal of hematology & oncology · 2017
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Frédéric BaronDepartment of Hematology, University of Liège, CHU Sart-Tilman, 4000, Liège, Belgium. f.baron@ulg.ac.be.
Myriam LabopinEBMT Paris Office, Hospital Saint Antoine, Paris, France. myriam.labopin@upmc.fr.
Annalisa RuggeriEurocord, Hospital Saint Louis, AP-HP, and IUH University Paris VII, Paris, France. annalisa.ruggeri@sat.aphp.fr.
Mohamad MohtyAP-HP, Hématologie Clinique et Thérapie Cellulaire, Hôpital Saint-Antoine, Paris, France. mohamad.mohty@inserm.fr.
Guillermo SanzHospital Universitario La Fe - Servicio de Hematologia, Valencia, Spain. sanz_gui@gva.es.
Noel MilpiedCHU Bordeaux - Hôpital Haut-leveque, Pessac, France. noel.milpied@chu-bordeaux.fr.
Andrea BacigalupoDepartment of Haematology II, Ospedale San Martino, Genova, Italy. andrea.bacigalupo@hsanmartino.it.
Alessandro RambaldiAzienda Ospedaliera Papa Giovanni XXIII-Hematology and Bone Marrow Transplant Unit, Bergamo, Italy. arambaldi@hpg23.it.
Francesca BonifaziInstitute of Hematology and Medical, Oncology L and A Seràgnoli, S.Orsola-Malpighi Hospital, Bologna University, Bologna, Italy. francesca.bonifazi@unibo.it.
Alberto BosiBMT Unit Department of Hematology, Ospedale di Careggi, Firenze, Italy. alberto.bosi@unifi.it.
Jorge SierraHematology Department, Hospital Santa Creu i Sant Pau, Barcelona, Spain. JSierra@santpau.cat.
Ibrahim Yakoub-AghaHôpital HURIEZ - UAM allo-CSH - CHRU, Lille, France. i-yakoub-agha@orange.fr.
Josep Maria Ribera SantasusanaICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras Research Institute, Barcelona, Spain. jribera@iconcologia.net.
Eliane GluckmanEurocord, Hospital Saint Louis, AP-HP, and IUH University Paris VII, France Monacord, Centre Scientifique de Monaco, Monaco, Monaco. eliane.gluckman@sls.aphp.fr.
Arnon NaglerEBMT Paris Office, Hospital Saint Antoine, Paris, France. Arnon.Nagler@sheba.health.gov.il.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the setting of allogeneic human leukocyte antigen (HLA)-matched bone marrow transplantation, transplanting male patients with grafts from female donors has been associated with a higher incidence of graft-versus-host disease (GVHD) and of nonrelapse mortality (NRM). The aim of the current analysis was to compare transplantation outcomes in male patients given female unrelated cord blood (UCB) versus other gender combinations. PATIENTS AND

methodsData from 552 consecutive patients with acute myeloid leukemia (AML) given a single UCB transplantation between 2000 and 2014 were included.

resultsIn comparison with other gender combination, male patients given female UCB (n = 131) had a trend for a higher incidence of grades II-IV acute GVHD (33 versus 25 %, P = 0.08), a trend for a higher incidence of NRM (41 versus 33 %, P = 0.06), and a lower leukemia-free (LFS, 30 versus 41 %, P = 0.01) and overall survival (OS, 33 versus 45 %, P = 0.008). In multivariate analyses, taking into consideration all patients for which data on HLA-matching and cell dose transplanted were fully available (n = 363), male patients transplanted with a female UCB had a trend for a higher incidence of grade III-IV acute GVHD (hazard ratio (HR) = 2.0, P = 0.06), a trend for a higher NRM (HR = 1.5, P = 0.06), and a worse LFS (HR = 1.4, P = 0.04) and OS (HR = 1.3, P = 0.06).

conclusionsOur data suggest that male patients transplanted with female UCB might have higher risk of acute GVHD and of NRM leading to worse LFS and OS. These results should be confirmed in other large cohorts of patients before used for determining the choice of an UCB unit.

Indexed as

Blood DonorsAcute DiseaseAdolescentAdultAgedCord Blood Stem Cell TransplantationEuropeFemaleGraft vs Host DiseaseHumansIncidenceLeukemia, MyeloidMaleMiddle AgedMultivariate AnalysisRetrospective Studies

Identifiers

PMID26445106
PMCPMC4594748

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.