Evidence map›Paper›PMID 26445093›Full record

ArticleBMC genomics2015

Transcriptomic analyses of regenerating adult feathers in chicken.

Chen Siang Ng, Chih-Kuan Chen, Wen-Lang Fan, Ping Wu, Siao-Man Wu, Jiun-Jie Chen, Yu-Ting Lai, Chi-Tang Mao, Mei-Yeh Jade Lu, Di-Rong Chen and 7 more

Open access · goldAbstract read
In one paragraph

Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Chen Siang NgBiodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan. gcsng@gate.sinica.edu.tw.
Chih-Kuan ChenBiodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan. r93b42016@gmail.com.
Wen-Lang FanBiodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan. alangfan@gmail.com.
Ping WuDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. Ping.Wu@med.usc.edu.
Siao-Man WuBiodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan. u941671@oz.nthu.edu.tw.
Jiun-Jie ChenBiodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan. Madvulcan0824@msn.com.
Yu-Ting LaiBiodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan. oswald1207@gmail.com.
Chi-Tang MaoBiodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan. jimmau@gate.sinica.edu.tw.
Mei-Yeh Jade LuBiodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan. meiyehlu@gate.sinica.edu.tw.
Di-Rong ChenBiodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan. cherrychen2835@gmail.com.
Ze-Shiang LinBiodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan. terrylin17@gmail.com.
Kai-Jung YangBiodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan. kwish101@gmail.com.
Yuan-An ShaDepartment of Animal Science, National Chung Hsing University, Taichung, 40227, Taiwan. shasha0919@yahoo.com.tw.
Tsung-Che TuDepartment of Animal Science, National Chung Hsing University, Taichung, 40227, Taiwan. tctu0523@gmail.com.
Chih-Feng ChenDepartment of Animal Science, National Chung Hsing University, Taichung, 40227, Taiwan. cfchen@dragon.nchu.edu.tw.
Cheng-Ming ChuongDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. cmchuong@med.usc.edu.
Wen-Hsiung LiBiodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan. whli@sinica.edu.tw.
Biodiversity Research Center, Academia Sinica · TWNational Chung Hsing University · TWUniversity of Southern California · USChang Gung Memorial Hospital · TW

Funding

Size regulation of skin appendagesR01AR047364 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Cheng-Ming Chuong · 2002 to 2026
$10.1M
LIW5R01AR042177 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUONG, CHENG-MING · 1995 to 2013
$5.7M
Tissue Engineering of New Hair FormationR01AR060306 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUONG, CHENG-MING · 2010 to 2019
$4.6M
NIAMS NIH HHS R01 AR042177NIAMS NIH HHS R01 AR047364NIAMS NIH HHS R01 AR060306
6 · The paper itself

Abstract

backgroundFeathers have diverse forms with hierarchical branching patterns and are an excellent model for studying the development and evolution of morphological traits. The complex structure of feathers allows for various types of morphological changes to occur. The genetic basis of the structural differences between different parts of a feather and between different types of feather is a fundamental question in the study of feather diversity, yet there is only limited relevant information for gene expression during feather development.

resultsWe conducted transcriptomic analysis of five zones of feather morphologies from two feather types at different times during their regeneration after plucking. The expression profiles of genes associated with the development of feather structure were examined. We compared the gene expression patterns in different types of feathers and different portions of a feather and identified morphotype-specific gene expression patterns. Many candidate genes were identified for growth control, morphogenesis, or the differentiation of specific structures of different feather types.

conclusionThis study laid the ground work for studying the evolutionary origin and diversification of feathers as abundant data were produced for the study of feather morphogenesis. It significantly increased our understanding of the complex molecular and cellular events in feather development processes and provided a foundation for future studies on the development of other skin appendages.

Indexed as

AnimalsCell DifferentiationChickensFeathersGene Expression ProfilingGene Expression Regulation, DevelopmentalMorphogenesisRegenerationSkinTranscriptome

Identifiers

PMID26445093
PMCPMC4594745
OpenAlexW1858959973

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.