ArticleInternational journal of environmental research and public health2015
Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features.
Article in International journal of environmental research and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- The impact of chemical pollution and warming on male fertility: a narrative review by the Special Interest Group "Environment and Fertility" of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR).Journal of assisted reproduction and genetics · 2025Review
- Endocrine-disrupting chemicals as prostate carcinogens.Nature reviews. Urology · 2025Review
- The impact of Bisphenol-A on human reproductive health.Toxicology reports · 2024Review
- The relationship between semen quality in male infertility clinic patients and bisphenol A：A Chinese cross-sectional study.Heliyon · 2024Article
- The Effects of Bisphenol A on Human Male Infertility: A Review of Current Epidemiological Studies.International journal of molecular sciences · 2023Review
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Endocrine-Disrupting Chemicals and Their Effects in Pet Dogs and Cats: An Overview.Animals : an open access journal from MDPI · 2023Review
- The Association between Bisphenol A, Steroid Hormones, and Selected MicroRNAs Levels in Seminal Plasma of Men with Infertility.Journal of clinical medicine · 2021Article
- The Impact of Endocrine-Disrupting Chemicals in Male Fertility: Focus on the Action of Obesogens.Journal of xenobiotics · 2021Review
- Environmental and occupational exposures associated with male infertility.Arhiv za higijenu rada i toksikologiju · 2021Review
- Companion animals get close to the toxic aspects of antropogenic world: cytotoxicity of phthalates and bisphenol A on dog testicular primary cells.Cytotechnology · 2020Article
- Association between polychlorinated biphenyl 153 exposure and serum testosterone levels: analysis of the National Health and Nutrition Examination Survey.Translational andrology and urology · 2019Article
- Development and Interlaboratory Validation of Two Fast UPLC-MS-MS Methods Determining Urinary Bisphenols, Parabens and Phthalates.Journal of analytical toxicology · 2019Article
- Independent and combined effects of diethylhexyl phthalate and polychlorinated biphenyl 153 on sperm quality in the human and dog.Scientific reports · 2019Article
- The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism.Cell metabolism · 2019Article
- "Bisphenol a: an emerging threat to male fertility".Reproductive biology and endocrinology : RB&E · 2019Review
- Water and soil pollution as determinant of water and food quality/contamination and its impact on male fertility.Reproductive biology and endocrinology : RB&E · 2019Review
- Decreased Capacity for Sperm Production Induced by Perinatal Bisphenol A Exposure Is Associated with an Increased Inflammatory Response in the Offspring of C57BL/6 Male Mice.International journal of environmental research and public health · 2018Article
- The LIFE PERSUADED project approach on phthalates and bisphenol A biomonitoring in Italian mother-child pairs linking exposure and juvenile diseases.Environmental science and pollution research international · 2018Article
- Impact of perfluorochemicals on human health and reproduction: a male's perspective.Journal of endocrinological investigation · 2018Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Internal levels of selected endocrine disruptors (EDs) (i.e., perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), di-2-ethylhexyl-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and bisphenol A (BPA)) were analyzed in blood/serum of infertile and fertile men from metropolitan, urban and rural Italian areas. PFOS and PFOA levels were also evaluated in seminal plasma. In peripheral blood mononuclear cells (PBMCs) of same subjects, gene expression levels of a panel of nuclear receptors (NRs), namely estrogen receptor α (ERα) estrogen receptor β (ERβ), androgen receptor (AR), aryl hydrocarbon receptor (AhR), peroxisome proliferator-activated receptor γ (PPARγ) and pregnane X receptor (PXR) were also assessed. Infertile men from the metropolitan area had significantly higher levels of BPA and gene expression of all NRs, except PPARγ, compared to subjects from other areas. Subjects from urban areas had significantly higher levels of MEHP, whereas subjects from rural area had higher levels of PFOA in both blood and seminal plasma. Interestingly, ERα, ERβ, AR, PXR and AhR expression is directly correlated with BPA and inversely correlated with PFOA serum levels. Our study indicates the relevance of the living environment when investigating the exposure to specific EDs. Moreover, the NRs panel in PBMCs demonstrated to be a potential biomarker of effect to assess the EDs impact on reproductive health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.