ArticleBMC medicine2015
Towards understanding the de-adoption of low-value clinical practices: a scoping review.
Article in BMC medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05975671 (Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis), which is not on this map. Cited by 185 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis (REVAMP-Sepsis)
Who cites it
185 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Learning health system for implementation, scale-up, and sustainment: a systematic review to consolidate guidance for improvement.Implementation science : IS · 2026Pooled it
- The VBHC big picture: an umbrella review.BMC health services research · 2025Pooled it
- Low-value interventions to deimplement: A secondary analysis of a systematic review of low back pain clinical practice guidelines.PM & R : the journal of injury, function, and rehabilitation · 2025Pooled it
- Electronic Health Record Nudges and Health Care Quality and Outcomes in Primary Care: A Systematic Review.JAMA network open · 2024Pooled it
- Determinants of the de-implementation of low-value care: a multi-method study.BMC health services research · 2022Pooled it
- De-implementing low-value care in cancer care delivery: a systematic review.Implementation science : IS · 2022Pooled it
- Effects of de-implementation strategies aimed at reducing low-value nursing procedures: a systematic review and meta-analysis.Implementation science : IS · 2020Pooled it
- Deimplementation of inappropriate feeding practices in early care and education: a Hybrid Type 3 cluster-randomized trial.Implementation science : IS · 2026Trial
- A cluster randomized stepped-wedge trial to de-implement unnecessary post-operative antibiotics in children: the optimizing perioperative antibiotic in children (OPerAtiC) trial.Implementation science : IS · 2021Trial
- The Sustain and Spread Framework: strategies for sustaining and spreading nutrition care improvements in acute care based on thematic analysis from the More-2-Eat study.BMC health services research · 2018Trial
- Effectiveness of educational outreach visits compared with usual guideline dissemination to improve family physician prescribing-an 18-month open cluster-randomized trial.Implementation science : IS · 2018Trial
- The effectiveness of a de-implementation strategy to reduce low-value blood management techniques in primary hip and knee arthroplasty: a pragmatic cluster-randomized controlled trial.Implementation science : IS · 2017Trial
- Paracetamol: A History of Assumptions, Errors, and Evidence Reversals in Pain Management.Current pain and headache reports · 2026Review
- From carbon cost to climate care: Greening our intensive care units.World journal of critical care medicine · 2026Review
- Drivers and potential mitigation solutions for low-value medical imaging in Iran: a qualitative study.BMJ open · 2026Article
- De-implementing spinal injections in pursuit of value-based care: Rethinking pain relief.The journal of pain · 2026Review
- Nationwide Implementation of Non-Mandatory Preventive Medicine Programmes in Japanese Municipalities: A Descriptive Cross-Sectional Survey and Evidence-Practice Gap Analysis.Research square · 2026Article
- De-implementation of low-value care: contrasting theories, models, and frameworks to generate methodological guidance.Implementation science communications · 2026Article
- From CXR to ultrasound: a multi-framework approach to advancing De-implementation in acute care.Implementation science communications · 2026Article
- Comparative effectiveness of non-reflective and reflective strategies to favor de-implementation of low-value prescribing for the primary prevention of cardiovascular disease in primary care: the DE-imFAR cluster randomized implementation trial.Implementation science communications · 2026Article
125 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow-value clinical practices are common in healthcare, yet the optimal approach to de-adopting these practices is unknown. The objective of this study was to systematically review the literature on de-adoption, document current terminology and frameworks, map the literature to a proposed framework, identify gaps in our understanding of de-adoption, and identify opportunities for additional research.
methodsMEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, the Cochrane Database of Abstracts and Reviews of Effects, and CINAHL Plus were searched from 1 January 1990 to 5 March 2014. Additional citations were identified from bibliographies of included citations, relevant websites, the PubMed 'related articles' function, and contacting experts in implementation science. English-language citations that referred to de-adoption of clinical practices in adults with medical, surgical, or psychiatric illnesses were included. Citation selection and data extraction were performed independently and in duplicate.
resultsFrom 26,608 citations, 109 were included in the final review. Most citations (65%) were original research with the majority (59%) published since 2010. There were 43 unique terms referring to the process of de-adoption-the most frequently cited was "disinvest" (39% of citations). The focus of most citations was evaluating the outcomes of de-adoption (50%), followed by identifying low-value practices (47%), and/or facilitating de-adoption (40%). The prevalence of low-value practices ranged from 16% to 46%, with two studies each identifying more than 100 low-value practices. Most articles cited randomized clinical trials (41%) that demonstrate harm (73%) and/or lack of efficacy (63%) as the reason to de-adopt an existing clinical practice. Eleven citations described 13 frameworks to guide the de-adoption process, from which we developed a model for facilitating de-adoption. Active change interventions were associated with the greatest likelihood of de-adoption.
conclusionsThis review identified a large body of literature that describes current approaches and challenges to de-adoption of low-value clinical practices. Additional research is needed to determine an ideal strategy for identifying low-value practices, and facilitating and sustaining de-adoption. In the meantime, this study proposes a model that providers and decision-makers can use to guide efforts to de-adopt ineffective and harmful practices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.