Evidence map›Paper›PMID 26444862›Full record

ArticleBMC medicine2015

Towards understanding the de-adoption of low-value clinical practices: a scoping review.

Daniel J Niven, Kelly J Mrklas, Jessalyn K Holodinsky, Sharon E Straus, Brenda R Hemmelgarn, Lianne P Jeffs, Henry Thomas Stelfox

Registry-linked trialAbstract readScoping Review
In one paragraph

Article in BMC medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05975671 (Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis), which is not on this map. Cited by 185 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
185citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05975671 narecruitingnot on this mapstarted 2023, after this paper: background citation

Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis (REVAMP-Sepsis)

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2023 to 2026Enrolled52,500ConditionsSepsis, Sepsis Mrsa, Sepsis Bacteremia, Antimicrobial - Induced NephropathyArmsMultifaceted de-implementation strategy to reduce vancomycin overuse
3 · Its place in the literature

Who cites it

185 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. The VBHC big picture: an umbrella review.BMC health services research · 2025
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  14. From carbon cost to climate care: Greening our intensive care units.World journal of critical care medicine · 2026
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125 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Daniel J NivenDepartment of Critical Care Medicine, University of Calgary, Calgary, Alberta, T1Y 6J4, Canada. Daniel.niven@albertahealthservices.ca.
Kelly J MrklasDepartment of Community Health Sciences, University of Calgary, Calgary, Alberta, T2N 4Z6, Canada. Kelly.mrklas@albertahealthservices.ca.
Jessalyn K HolodinskyDepartment of Community Health Sciences, University of Calgary, Calgary, Alberta, T2N 4Z6, Canada. jkholodi@ucalgary.ca.
Sharon E StrausLi Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, M5B 1T8, Canada. Sharon.straus@utoronto.ca.
Brenda R HemmelgarnDepartment of Community Health Sciences, University of Calgary, Calgary, Alberta, T2N 4Z6, Canada. Brenda.hemmelgarn@albertahealthservices.ca.
Lianne P JeffsLi Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, M5B 1T8, Canada. jeffsl@smh.ca.
Henry Thomas StelfoxDepartment of Critical Care Medicine, University of Calgary, Calgary, Alberta, T1Y 6J4, Canada. tstelfox@ucalgary.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow-value clinical practices are common in healthcare, yet the optimal approach to de-adopting these practices is unknown. The objective of this study was to systematically review the literature on de-adoption, document current terminology and frameworks, map the literature to a proposed framework, identify gaps in our understanding of de-adoption, and identify opportunities for additional research.

methodsMEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, the Cochrane Database of Abstracts and Reviews of Effects, and CINAHL Plus were searched from 1 January 1990 to 5 March 2014. Additional citations were identified from bibliographies of included citations, relevant websites, the PubMed 'related articles' function, and contacting experts in implementation science. English-language citations that referred to de-adoption of clinical practices in adults with medical, surgical, or psychiatric illnesses were included. Citation selection and data extraction were performed independently and in duplicate.

resultsFrom 26,608 citations, 109 were included in the final review. Most citations (65%) were original research with the majority (59%) published since 2010. There were 43 unique terms referring to the process of de-adoption-the most frequently cited was "disinvest" (39% of citations). The focus of most citations was evaluating the outcomes of de-adoption (50%), followed by identifying low-value practices (47%), and/or facilitating de-adoption (40%). The prevalence of low-value practices ranged from 16% to 46%, with two studies each identifying more than 100 low-value practices. Most articles cited randomized clinical trials (41%) that demonstrate harm (73%) and/or lack of efficacy (63%) as the reason to de-adopt an existing clinical practice. Eleven citations described 13 frameworks to guide the de-adoption process, from which we developed a model for facilitating de-adoption. Active change interventions were associated with the greatest likelihood of de-adoption.

conclusionsThis review identified a large body of literature that describes current approaches and challenges to de-adoption of low-value clinical practices. Additional research is needed to determine an ideal strategy for identifying low-value practices, and facilitating and sustaining de-adoption. In the meantime, this study proposes a model that providers and decision-makers can use to guide efforts to de-adopt ineffective and harmful practices.

Indexed as

Quality ImprovementDecision MakingHumansPatient SafetyPeer Review, Health CarePractice Patterns, Physicians'Utilization Review

Identifiers

PMID26444862
PMCPMC4596285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.