Evidence map›Paper›PMID 26444849›Full record

ArticleThe journal of knee surgery2016

Open Knee: Open Source Modeling and Simulation in Knee Biomechanics.

Ahmet Erdemir

Open access · greenAbstract read
In one paragraph

Article in The journal of knee surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
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  9. Validation of a Finite Element Simulation for Predicting Individual Knee Joint Kinematics.IEEE open journal of engineering in medicine and biology · 2024
    Article
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  13. Assessment of reporting practices and reproducibility potential of a cohort of published studies in computational knee biomechanics.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
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  18. Biomechanical Characteristics of the Knee Joint during Gait in Obese versus Normal Subjects.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Ahmet ErdemirComputational Biomodeling (CoBi) Core and Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio.
Cleveland Clinic · US

Funding

Physics-based Simulation of Biological Structures(RMI)U54GM072970 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO · 2004 to 2013
$33.5M
Finite Elements For Biomechanics And BiophysicsR01GM083925 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI GERARD A. ATESHIAN, JEFFREY A. WEISS · 2008 to 2026
$7.6M
IDENTIFYING FEMALE ATHLETES AT HIGH RISK FOR ACL INJURYR01AR049735 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI HEWETT, TIMOTHY E · 2004 to 2008
$2.6M
Open Knee(s): Virtual Biomechanical Representations of the Knee JointR01GM104139 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI ERDEMIR, AHMET · 2013 to 2016
$2.1M
Predicting cell deformation from body level mechanical loadsR01EB009643 · NIBIB · CLEVELAND CLINIC LERNER COM-CWRU · PI ERDEMIR, AHMET · 2009 to 2012
$1.7M
NIAMS NIH HHS R01 AR049735NIAMS NIH HHS R01AR049735NIBIB NIH HHS R01 EB009643NIBIB NIH HHS R01EB009643NIGMS NIH HHS R01 GM083925NIGMS NIH HHS R01GM083925NIGMS NIH HHS R01 GM104139NIGMS NIH HHS R01GM104139NIGMS NIH HHS U54 GM072970NIGMS NIH HHS U54GM072970
6 · The paper itself

Abstract

Virtual representations of the knee joint can provide clinicians, scientists, and engineers the tools to explore mechanical functions of the knee and its tissue structures in health and disease. Modeling and simulation approaches such as finite element analysis also provide the possibility to understand the influence of surgical procedures and implants on joint stresses and tissue deformations. A large number of knee joint models are described in the biomechanics literature. However, freely accessible, customizable, and easy-to-use models are scarce. Availability of such models can accelerate clinical translation of simulations, where labor-intensive reproduction of model development steps can be avoided. Interested parties can immediately utilize readily available models for scientific discovery and clinical care. Motivated by this gap, this study aims to describe an open source and freely available finite element representation of the tibiofemoral joint, namely Open Knee, which includes the detailed anatomical representation of the joint's major tissue structures and their nonlinear mechanical properties and interactions. Three use cases illustrate customization potential of the model, its predictive capacity, and its scientific and clinical utility: prediction of joint movements during passive flexion, examining the role of meniscectomy on contact mechanics and joint movements, and understanding anterior cruciate ligament mechanics. A summary of scientific and clinically directed studies conducted by other investigators are also provided. The utilization of this open source model by groups other than its developers emphasizes the premise of model sharing as an accelerator of simulation-based medicine. Finally, the imminent need to develop next-generation knee models is noted. These are anticipated to incorporate individualized anatomy and tissue properties supported by specimen-specific joint mechanics data for evaluation, all acquired in vitro from varying age groups and pathological states.

Indexed as

Computer SimulationKnee JointModels, BiologicalAccess to InformationAgedBiomechanical PhenomenaCadaverFemaleFinite Element AnalysisHumans

Identifiers

PMID26444849
PMCPMC4876308
OpenAlexW2295618158

What OpenQuestion holds

Textmetadata
LicenceCC BY-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.