ArticleJournal of acquired immune deficiency syndromes (1999)2016
The J-Curve in HIV: Low and Moderate Alcohol Intake Predicts Mortality but Not the Occurrence of Major Cardiovascular Events.
Article in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Harmonization of alcohol use data and mortality across a multi-national HIV cohort collaboration.Alcohol, clinical & experimental research · 2025Article
- Contribution of alcohol use in HIV/hepatitis C virus co-infection to all-cause and cause-specific mortality: A collaboration of cohort studies.Journal of viral hepatitis · 2023Article
- The Eyeball Test.Ochsner journal · 2023Article
- The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study.Journal of clinical medicine · 2021Article
- Contribution of Behavioral Health Factors to Non-AIDS-Related Comorbidities: an Updated Review.Current HIV/AIDS reports · 2020Review
- HIV care provider perceptions and approaches to managing unhealthy alcohol use in primary HIV care settings: a qualitative study.Addiction science & clinical practice · 2019Article
- Patterns of Alcohol Use Among Patients Living With HIV in Urban, Large Rural, and Small Rural Areas.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2019Article
- Racial/ethnic differences in the association between alcohol use and mortality among men living with HIV.Addiction science & clinical practice · 2018Article
- Association between alcohol consumption trajectories and clinical profiles among women and men living with HIV.The American journal of drug and alcohol abuse · 2018Article
- The impact of long-term moderate and heavy alcohol consumption on incident atherosclerosis among persons living with HIV.Drug and alcohol dependence · 2017Article
- Alcohol Use, HIV Treatment Adherence, and Sexual Risk Among People with a History of Injecting Drug Use in Vietnam.AIDS and behavior · 2017Article
- The Role of Current and Historical Alcohol Use in Hepatic Fibrosis Among HIV-Infected Individuals.AIDS and behavior · 2017Article
- Predictors of immunodeficiency-related death in a cohort of low-income people living with HIV: a competing risks survival analysis.Epidemiology and infection · 2017Article
- Observational
- Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions.Alcoholism, clinical and experimental research · 2016Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn HIV-negative populations, light-to-moderate alcohol consumption is associated with a lower cardiovascular morbidity and mortality than alcohol abstention. Whether the same holds true for HIV-infected individuals has not been evaluated in detail.
designCohort study.
methodsAdults on antiretroviral therapy in the Swiss HIV Cohort Study with follow-up after August 2005 were included. We categorized alcohol consumption into: abstention or very low (<1 g/d), low (1-9 g/d), moderate (10-29 g/d in women and 10-39 g/d in men), and high alcohol intake. Cox proportional hazards models were used to describe the association between alcohol consumption and cardiovascular disease-free survival (combined endpoint), cardiovascular disease events (CADE) and overall survival. Baseline and time-updated risk factors for CADE were included in the models.
resultsAmong 9741 individuals included, there were 788 events of major CADE or death during 46,719 patient-years of follow-up, corresponding to an incidence of 1.69 events/100 person-years. Follow-up according to alcohol consumption level was 51% no or very low, 20% low, 23% moderate, and 6% high intake. As compared with no or very low alcohol intake, low (hazard ratio 0.79, 95% confidence interval 0.63 to 0.98) and moderate alcohol intakes (0.78, 0.64 to 0.95) were associated with a lower incidence of the combined endpoint. There was no significant association between alcohol consumption and CADE.
conclusionsCompared with no or very low alcohol consumption, low and moderate intake associated with a better CADE-free survival. However, this result was mainly driven by mortality and the specific impact of drinking patterns and type of alcoholic beverage on this outcome remains to be determined.
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