Evidence map›Paper›PMID 26444082›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2016

Grapefruit-derived Nanovectors Delivering Therapeutic miR17 Through an Intranasal Route Inhibit Brain Tumor Progression.

Xiaoying Zhuang, Yun Teng, Abhilash Samykutty, Jingyao Mu, Zhongbin Deng, Lifeng Zhang, Pengxiao Cao, Yuan Rong, Jun Yan, Donald Miller and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 2 syntheses or guidelines pooled it, 253 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Natural Product-Derived Vesicles in Nanotherapeutics.Journal of extracellular vesicles · 2026
    Review
  4. Green nanomedicine for cancer therapy.Chinese medical journal · 2026
    Review
  5. Article
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  8. Article
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  13. Therapeutic potential of garlic-derived exosome like nanovesicles: challenge and opportunity.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026
    Review
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105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xiaoying ZhuangBrown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA.
Yun TengBrown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA.
Abhilash SamykuttyBrown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA.
Jingyao MuBrown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA.
Zhongbin DengBrown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA.
Lifeng ZhangBrown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA.
Pengxiao CaoBrown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA.
Yuan RongBrown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA.
Jun YanBrown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA.
Donald MillerBrown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA.
Huang-Ge ZhangBrown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA.
University of Louisville · US

Funding

Plant exosomes non-coding RNA-mediated anti-inflammatory mechanismsR01AT008617 · NCCIH · UNIVERSITY OF LOUISVILLE · PI HUANG-GE ZHANG · 2016 to 2026
$5.7M
Fruit exosome-like particles for therapeutic delivery of extracellular miRNAsUH3TR000875 · NCATS · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2015 to 2017
$2.7M
Curcumin reverses tumor exosomes-mediated inhibition of myeloid differentiationR01AT004294 · NCCIH · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2007 to 2010
$1.4M
Fruit exosome-like particles for therapeutic delivery of extracellular miRNAsUH2TR000875 · NCATS · UNIVERSITY OF LOUISVILLE · PI GUO, PEIXUAN, ZHANG, HUANG-GE · 2013 to 2014
$867k
Exosomal TRAF2-CSN5 complex mediated inflammation promotes tumor growthI01BX000962 · VA · LOUISVILLE VA MEDICAL MEDICAL CENTER · PI ZHANG, HUANG-GE · 2011 to 2014
–
BLRD VA I01 BX000962NCATS NIH HHS UH2 TR000875NCATS NIH HHS UH2TR000875NCATS NIH HHS UH3 TR000875NCCIH NIH HHS R01 AT004294NCCIH NIH HHS R01 AT008617
6 · The paper itself

Abstract

The lack of access to the brain is a major obstacle for central nervous system drug development. In this study, we demonstrate the capability of a grapefruit-derived nanovector (GNV) to carry miR17 for therapeutic treatment of mouse brain tumor. We show that GNVs coated with folic acid (FA-GNVs) are enhanced for targeting the GNVs to a folate receptor-positive GL-26 brain tumor. Additionally, FA-GNV-coated polyethylenimine (FA-pGNVs) not only enhance the capacity to carry RNA, but the toxicity of the polyethylenimine is eliminated by the GNVs. Intranasal administration of miR17 carried by FA-pGNVs led to rapid delivery of miR17 to the brain that was selectively taken up by GL-26 tumor cells. Mice treated intranasally with FA-pGNV/miR17 had delayed brain tumor growth. Our results demonstrate that this strategy may provide a noninvasive therapeutic approach for treating brain-related disease through intranasal delivery.

Indexed as

Administration, IntranasalAnimalsBrain NeoplasmsCell Line, TumorCitrus paradisiDisease ProgressionFolic AcidGenetic TherapyMiceMicroRNAsNanoparticlesOrgan SpecificityPlant ExtractsPolyethyleneimineTreatment OutcomeXenograft Model Antitumor AssaysFolic AcidMicroRNAsMirn17 microRNA, mousePlant ExtractsPolyethyleneimine

Identifiers

PMID26444082
PMCPMC4754550
OpenAlexW2223281187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.