Evidence map›Paper›PMID 26444076›Full record

ArticleBiological psychiatry2016

Maternal Exposure to Childhood Trauma Is Associated During Pregnancy With Placental-Fetal Stress Physiology.

Nora K Moog, Claudia Buss, Sonja Entringer, Babak Shahbaba, Daniel L Gillen, Calvin J Hobel, Pathik D Wadhwa

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
10.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 126 citations in OpenAlex.

  1. Trial
  2. Review
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  4. The Prenatal in Lacan's Borromean Knot.American journal of psychoanalysis · 2026
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Nora K MoogDevelopment, Health, and Disease Research Program, University of California, Irvine, Orange, California; Department of Medical Psychology, Charité University Medicine Berlin, Berlin, Germany.
Claudia BussDevelopment, Health, and Disease Research Program, University of California, Irvine, Orange, California; Department of Medical Psychology, Charité University Medicine Berlin, Berlin, Germany; Department of Pediatrics, University of California, Irvine, School of Medicine, Orange.
Sonja EntringerDevelopment, Health, and Disease Research Program, University of California, Irvine, Orange, California; Department of Medical Psychology, Charité University Medicine Berlin, Berlin, Germany; Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles.
Babak ShahbabaDepartment of Statistics, University of California, Irvine, Irvine.
Daniel L GillenDepartment of Statistics, University of California, Irvine, Irvine.
Calvin J HobelDepartment of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles.
Pathik D WadhwaDevelopment, Health, and Disease Research Program, University of California, Irvine, Orange, California; Department of Pediatrics, University of California, Irvine, School of Medicine, Orange; Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles; Departments of Psychiatry and Human Behavior, University of California, Irvine, School of Medicine, Orange, Irvine, California; Obstetrics and Gynecology, University of California, Irvine, School of Medicine, Orange, Irvine, California; Department of Epidemiology, University of California, Irvine, School of Medicine, Irvine, California. Electronic address: pwadhwa@uci.edu.
University of California, Irvine · USCharité - Universitätsmedizin Berlin · DECedars-Sinai Medical Center · US

Funding

PROJECT I POPULATION STRUCTURE OF GENETIC VARIATION IN PREGNANCYP01HD047609 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2005 to 2009
$4.9M
Intergenerational Effects of Maternal Childhood Trauma on the Fetal BrainR01MH105538 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, FAIR, DAMIEN A · 2015 to 2019
$3.5M
EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
Maternal Stress and Fetal/Infant DevelopmentR01NS041298 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMAN, CURT ALAN · 2002 to 2006
$2.8M
STRESS BIOLOGY, RACE/ETHNICITY &INFECTION IN PREGNANCYR01HD041696 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2002 to 2006
$2.1M
PHYSIOLOGICAL STRESS REACTIVITY AND PREGNANCY OUTCOMESR29HD033506 · NICHD · UNIVERSITY OF KENTUCKY · PI WADHWA, PATHIK D · 1998 to 2002
$306k
NICHD NIH HHS P01 HD047609NICHD NIH HHS R01 HD041696NICHD NIH HHS R01 HD060628NICHD NIH HHS R29 HD033506NIMH NIH HHS R01 MH105538NINDS NIH HHS R01 NS041298
6 · The paper itself

Abstract

backgroundThe effects of exposure to childhood trauma (CT) may be transmitted across generations; however, the time period(s) and mechanism(s) have yet to be clarified. We address the hypothesis that intergenerational transmission may begin during intrauterine life via the effect of maternal CT exposure on placental-fetal stress physiology, specifically placental corticotropin-releasing hormone (pCRH).

methodsThe study was conducted in a sociodemographically diverse cohort of 295 pregnant women. CT exposure was assessed using the Childhood Trauma Questionnaire. Placental CRH concentrations were quantified in maternal blood collected serially over the course of gestation. Linear mixed effects and Bayesian piece-wise linear models were employed to test hypothesized relationships.

resultsMaternal CT exposure (CT+) was significantly associated with pCRH production. Compared with nonexposed women, CT+ was associated with an almost 25% increase in pCRH toward the end of gestation, and the pCRH trajectory of CT+ women exhibited an approximately twofold steeper increase after the pCRH inflection point at 19 weeks gestation.

conclusionsTo the best of our knowledge, this finding represents the first report linking maternal CT exposure with placental-fetal stress physiology, thus identifying a potential novel biological pathway of intergenerational transmission that may operate as early as during intrauterine life.

Indexed as

Child AbuseStress, PhysiologicalAdultBayes TheoremChildCorticotropin-Releasing HormoneFemaleFetal DiseasesHumansLinear ModelsLongitudinal StudiesMaternal ExposurePlacenta DiseasesPregnancyProspective StudiesSocioeconomic FactorsCorticotropin-Releasing HormoneChildhood traumaDevelopmental programmingIntergenerational transmissionPlacental CRHPreconceptional stressPregnancy

Identifiers

PMID26444076
PMCPMC4777678
OpenAlexW1228738336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.