ArticleJournal of magnetic resonance imaging : JMRI2016
Fully automatic analysis of the knee articular cartilage T1ρ relaxation time using voxel-based relaxometry.
Article in Journal of magnetic resonance imaging : JMRI, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Automated Segmentation of Tissues Using CT and MRI: A Systematic Review.Academic radiology · 2019Pooled it
- MRI T2 and T1ρ relaxation in patients at risk for knee osteoarthritis: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2019Pooled it
- A novel mr-based method for detection of cartilage delamination in femoroacetabular impingement patients.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Trial
- Relationship Between Early Cartilage Degeneration With T1ρ and T2 Analysis in Medial Tibial Cartilage and 10-Year Posttraumatic Osteoarthritis Progression After ACL Reconstruction.The American journal of sports medicine · 2025Article
- TJournal of magnetic resonance imaging : JMRI · 2025Article
- Which Endpoints Should be Applied in Interventional Trials? -: From Single Uni-dimensional Assessment Tailored to a Drug's Mechanism of Action to Multi-Component Measures and Multi-Domain Composites.Osteoarthritis imaging · 2025Article
- Longitudinal Changes in Medial Meniscal Extrusion After ACL Injury and Reconstruction and Its Relationship With Cartilage Degeneration Assessed Using MRI-Based T1ρ and T2 Analysis.The American journal of sports medicine · 2025Article
- Revealing Detailed Cartilage Function Through Nanoparticle Diffusion Imaging: A Computed Tomography & Finite Element Study.Annals of biomedical engineering · 2024Article
- Multiparametric MRI of Knees in Collegiate Basketball Players: Associations With Morphological Abnormalities and Functional Deficits.Orthopaedic journal of sports medicine · 2023Article
- Methods for the Clinical Translation of Quantitative MRI for the Evaluation of Patients With Femoroacetabular Impingement.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2023Article
- A Correspondence-Based Network Approach for Groupwise Analysis of Patient-Specific Spatiotemporal Data.Annals of biomedical engineering · 2023Article
- Persistent underloading of patellofemoral joint following hamstring autograft ACL reconstruction is associated with cartilage health.Osteoarthritis and cartilage · 2023Article
- Baseline cartilage T1ρ and T2 predicted patellofemoral joint cartilage lesion progression and patient-reported outcomes after ACL reconstruction.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Design and validation of a semi-automatic bone segmentation algorithm from MRI to improve research efficiency.Scientific reports · 2022Article
- Obesity impacts the mechanical response and biochemical composition of patellofemoral cartilage: An in vivo, MRI-based investigation.Journal of biomechanics · 2022Article
- A transfer learning approach for automatic segmentation of the surgically treated anterior cruciate ligament.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Review
- A new technique to evaluate the impact of running on knee cartilage deformation by region.Magma (New York, N.Y.) · 2021Article
- Multivariate functional principal component analysis identifies waveform features of gait biomechanics related to early-to-moderate hip osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Multiparametric MRI characterization of knee articular cartilage and subchondral bone shape in collegiate basketball players.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeTo develop and compare with the classical region of interest (ROI)-based approach a fully automatic, local, and unbiased way of studying the knee T1ρ relaxation time by creating an atlas and using voxel-based relaxometry (VBR) in osteoarthritis (OA) and anterior cruciate ligament (ACL) subjects. MATERIALS AND
methodsIn this study 110 subjects from two cohorts: 1) Mild OA 40 patients with mild-OA Kellgren-Lawrence (KL) ≤ 2 and 15 controls KL ≤ 1; 2) ACL cohort (a model for early OA): 40 ACL-injured patients imaged prior to ACL reconstruction and 1-year postsurgery and 15 controls are analyzed. All the subjects were acquired at 3T with a protocol that includes: 3D-FSE (CUBE) and 3D-T1ρ . A nonrigid registration technique was applied to align all the images on a single template. This allows for performing VBR to assess local statistical differences of T1ρ values using z-score analysis. VBR results were compared with those obtained with classical ROI-based technique.
resultsROI-based results from atlas-based segmentation were consistent with classical ROI-based method (coefficient of variation [CV] = 3.83%). Voxel-based group analysis revealed local patterns that were overlooked by the ROI-based approach; eg, VBR showed posterior lateral femur and posterior lateral tibia significant T1ρ elevations in ACL-injured patients (sample mean z-score=9.7 and 10.3). Those elevations were overlooked by the classical ROI-based approach (sample mean z-score=1.87 and -1.73)
conclusionVBR is a feasible and accurate tool for the local evaluation of the biochemical composition of knee articular cartilage. VBR is capable of detecting specific local patterns on T1ρ maps in OA and ACL subjects.
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Registered trials
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