Evidence map›Paper›PMID 26443800›Full record

ArticleTechnology in cancer research & treatment2016

Feasibility of a Modified Biopsy Needle for Irreversible Electroporation Ablation and Periprocedural Tissue Sampling.

Thomas Wimmer, Govindarajan Srimathveeravalli, Mikhail Silk, Sebastien Monette, Narendra Gutta, Majid Maybody, Joseph P Erinjery, Jonathan A Coleman, Stephen B Solomon, Constantinos T Sofocleous

Open access · bronzeAbstract read
In one paragraph

Article in Technology in cancer research & treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Thomas WimmerInterventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA thomas.wimmer@medunigraz.at.
Govindarajan SrimathveeravalliInterventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Mikhail SilkInterventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Sebastien MonetteLaboratory of Comparative Pathology, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, The Rockefeller University, New York, NY, USA.
Narendra GuttaInterventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Majid MaybodyInterventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Joseph P ErinjeryInterventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Jonathan A ColemanUrology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Stephen B SolomonInterventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Constantinos T SofocleousInterventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Memorial Sloan Kettering Cancer Center · USMedical University of Graz · AT

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

objectivesTo test the feasibility of modified biopsy needles as probes for irreversible electroporation ablation and periprocedural biopsy.

methodsCore biopsy needles of 16-G/9-cm were customized to serve as experimental ablation probes. Computed tomography-guided percutaneous irreversible electroporation was performed in in vivo porcine kidneys with pairs of experimental (n = 10) or standard probes (n = 10) using a single parameter set (1667 V/cm, ninety 100 µs pulses). Two biopsy samples were taken immediately following ablation using the experimental probes (n = 20). Ablation outcomes were compared using computed tomography, simulation, and histology. Biopsy and necropsy histology were compared.

resultsSimulation-suggested ablations with experimental probes were smaller than that with standard electrodes (455.23 vs 543.16 mm

conclusionsA combined probe for irreversible electroporation ablation and periprocedural tissue sampling from the ablation zone is feasible. Ablation outcomes are comparable to those of standard electrodes.

Indexed as

Ablation TechniquesAnimalsBiopsy, NeedleElectroporationFemaleKidneyNeedlesSwineTomography, X-Ray Computedablation techniquecomputed tomographycore needle biopsyirreversible electroporationkidney

Identifiers

PMID26443800
PMCPMC5495023
OpenAlexW2292567495

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.