Evidence map›Paper›PMID 26443701›Full record

ReviewJournal of neural transmission (Vienna, Austria : 1996)2016

The rationale for deep brain stimulation in Alzheimer's disease.

Zaman Mirzadeh, Ausaf Bari, Andres M Lozano

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neural transmission (Vienna, Austria : 1996), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
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  12. Article
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  14. Article
  15. Multimodal Encoding of Novelty, Reward, and Learning in the Primate Nucleus Basalis of Meynert.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  16. Article
  17. Brain Stimulation in Alzheimer's Disease.Frontiers in psychiatry · 2018
    Review
  18. Deep brain stimulation for Alzheimer's Disease: An update.Surgical neurology international · 2018
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Zaman MirzadehDivision of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Ausaf BariDivision of Neurosurgery, University of Toronto, Toronto, ON, Canada.
Andres M LozanoDivision of Neurosurgery, University of Toronto, Toronto, ON, Canada. lozano@uhnresearch.ca.
University of Toronto · CASt. Joseph's Hospital and Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease is a major worldwide health problem with no effective therapy. Deep brain stimulation (DBS) has emerged as a useful therapy for certain movement disorders and is increasingly being investigated for treatment of other neural circuit disorders. Here we review the rationale for investigating DBS as a therapy for Alzheimer's disease. Phase I clinical trials of DBS targeting memory circuits in Alzheimer's disease patients have shown promising results in clinical assessments of cognitive function, neurophysiological tests of cortical glucose metabolism, and neuroanatomical volumetric measurements showing reduced rates of atrophy. These findings have been supported by animal studies, where electrical stimulation of multiple nodes within the memory circuit have shown neuroplasticity through stimulation-enhanced hippocampal neurogenesis and improved performance in memory tasks. The precise mechanisms by which DBS may enhance memory and cognitive functions in Alzheimer's disease patients and the degree of its clinical efficacy continue to be examined in ongoing clinical trials.

Indexed as

Alzheimer DiseaseBasal Nucleus of MeynertBrainCognition DisordersDeep Brain StimulationHumansNeuroimagingAlzheimer’s diseaseCognitionDeep brain stimulationDementiaFornixNucleus basalis of Meynert

Identifiers

PMID26443701
OpenAlexW1848067291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.