ArticlePlant physiology2015
The Tomato MIXTA-Like Transcription Factor Coordinates Fruit Epidermis Conical Cell Development and Cuticular Lipid Biosynthesis and Assembly.
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Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed, 111 citations in OpenAlex.
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- Network ontology transcript annotation identifies genetic signals underlying sex determination.Scientific reports · 2026Article
- Insights into glandular trichome biology from analysis of organ-specific gene expression programmes in cannabis, hop and tomato.The Plant journal : for cell and molecular biology · 2026Article
- Molecular Evolution of the NLR Gene Family Reveals Diverse Innate Immune Strategies in Bats.Biomolecules · 2025Article
- Mitochondrial GPATs protect Arabidopsis from water stress by impacting cuticle and secondary cell wall development.Plant cell reports · 2025Article
- Functional characterization of AarMIXTAs as essential regulators in T-shaped non-glandular trichome development of Artemisia argyi.Advanced biotechnology · 2025Article
- Mutations in BrMYB31 lead to a glossy phenotype caused by a deficiency in epidermal wax crystals in Chinese cabbage.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- CRABS CLAW-independent floral nectary development in Penstemon barbatus.American journal of botany · 2025Article
- Cytochromes P450 evolution in the plant terrestrialization context.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Fruit ripening and postharvest changes in very early-harvested tomatoes.Horticulture research · 2024Article
- The Impact of Growing Area on the Expression of Fruit Traits Related to Sensory Perception in Two Tomato Cultivars.International journal of molecular sciences · 2024Article
- Genome-wide characterization and expression profiling of E2F/DP gene family members in response to abiotic stress in tomato (Solanum lycopersicum L.).BMC plant biology · 2024Article
- MdBT2 regulates nitrogen-mediated cuticular wax biosynthesis via a MdMYB106-MdCER2L1 signalling pathway in apple.Nature plants · 2024Article
- Characterisation of the R2R3 Myb subgroup 9 family of transcription factors in tomato.PloS one · 2024Article
- Beyond skin-deep: targeting the plant surface for crop improvement.Journal of experimental botany · 2023Review
- Regulation of capsule spine formation in castor.Plant physiology · 2023Article
- Fine mapping and candidate gene analysis of CaFCD1 affecting cuticle biosynthesis in Capsicum annuum L.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- A eudicotFrontiers in plant science · 2023Article
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Authors and funding
13 authors at 7 institutions in 5 countries.
Justin LashbrookeDepartment of Plant Sciences (J.L., A.Ad., O.L., N.A., T.T., J.-P.F.-M., A.Ah.) andChemical Research Support (K.R.), Weizmann Institute of Science, Rehovot 76100, Israel;Research and Innovation Centre, Foundation Edmund Mach, I-38010 San Michele all'Adige, Trento, Italy (J.L., F.C.);Institute for Wine Biotechnology, Stellenbosch University, Stellenbosch 7602, South Africa (J.L.);Department of Postharvest Science of Fresh Fruit, The Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel (N.A.);Department of Plant Breeding and Biotechnology, Instituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (J.-P.F.-M., A.G.); andDépartement Réseaux Métaboliques chez les Végétaux, Institut de Biologie Molééculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Université de Strasbourg, 67083 Strasbourg cedex, France (E.W., B.G., F.P.).ORCID http://orcid.org/0000-0003-4511-4215
Avital AdatoDepartment of Plant Sciences (J.L., A.Ad., O.L., N.A., T.T., J.-P.F.-M., A.Ah.) andChemical Research Support (K.R.), Weizmann Institute of Science, Rehovot 76100, Israel;Research and Innovation Centre, Foundation Edmund Mach, I-38010 San Michele all'Adige, Trento, Italy (J.L., F.C.);Institute for Wine Biotechnology, Stellenbosch University, Stellenbosch 7602, South Africa (J.L.);Department of Postharvest Science of Fresh Fruit, The Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel (N.A.);Department of Plant Breeding and Biotechnology, Instituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (J.-P.F.-M., A.G.); andDépartement Réseaux Métaboliques chez les Végétaux, Institut de Biologie Molééculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Université de Strasbourg, 67083 Strasbourg cedex, France (E.W., B.G., F.P.).ORCID http://orcid.org/0000-0002-7430-0079
Orfa LotanDepartment of Plant Sciences (J.L., A.Ad., O.L., N.A., T.T., J.-P.F.-M., A.Ah.) andChemical Research Support (K.R.), Weizmann Institute of Science, Rehovot 76100, Israel;Research and Innovation Centre, Foundation Edmund Mach, I-38010 San Michele all'Adige, Trento, Italy (J.L., F.C.);Institute for Wine Biotechnology, Stellenbosch University, Stellenbosch 7602, South Africa (J.L.);Department of Postharvest Science of Fresh Fruit, The Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel (N.A.);Department of Plant Breeding and Biotechnology, Instituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (J.-P.F.-M., A.G.); andDépartement Réseaux Métaboliques chez les Végétaux, Institut de Biologie Molééculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Université de Strasbourg, 67083 Strasbourg cedex, France (E.W., B.G., F.P.).
Noam AlkanDepartment of Plant Sciences (J.L., A.Ad., O.L., N.A., T.T., J.-P.F.-M., A.Ah.) andChemical Research Support (K.R.), Weizmann Institute of Science, Rehovot 76100, Israel;Research and Innovation Centre, Foundation Edmund Mach, I-38010 San Michele all'Adige, Trento, Italy (J.L., F.C.);Institute for Wine Biotechnology, Stellenbosch University, Stellenbosch 7602, South Africa (J.L.);Department of Postharvest Science of Fresh Fruit, The Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel (N.A.);Department of Plant Breeding and Biotechnology, Instituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (J.-P.F.-M., A.G.); andDépartement Réseaux Métaboliques chez les Végétaux, Institut de Biologie Molééculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Université de Strasbourg, 67083 Strasbourg cedex, France (E.W., B.G., F.P.).
Tatiana TsimbalistDepartment of Plant Sciences (J.L., A.Ad., O.L., N.A., T.T., J.-P.F.-M., A.Ah.) andChemical Research Support (K.R.), Weizmann Institute of Science, Rehovot 76100, Israel;Research and Innovation Centre, Foundation Edmund Mach, I-38010 San Michele all'Adige, Trento, Italy (J.L., F.C.);Institute for Wine Biotechnology, Stellenbosch University, Stellenbosch 7602, South Africa (J.L.);Department of Postharvest Science of Fresh Fruit, The Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel (N.A.);Department of Plant Breeding and Biotechnology, Instituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (J.-P.F.-M., A.G.); andDépartement Réseaux Métaboliques chez les Végétaux, Institut de Biologie Molééculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Université de Strasbourg, 67083 Strasbourg cedex, France (E.W., B.G., F.P.).
Katya RechavDepartment of Plant Sciences (J.L., A.Ad., O.L., N.A., T.T., J.-P.F.-M., A.Ah.) andChemical Research Support (K.R.), Weizmann Institute of Science, Rehovot 76100, Israel;Research and Innovation Centre, Foundation Edmund Mach, I-38010 San Michele all'Adige, Trento, Italy (J.L., F.C.);Institute for Wine Biotechnology, Stellenbosch University, Stellenbosch 7602, South Africa (J.L.);Department of Postharvest Science of Fresh Fruit, The Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel (N.A.);Department of Plant Breeding and Biotechnology, Instituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (J.-P.F.-M., A.G.); andDépartement Réseaux Métaboliques chez les Végétaux, Institut de Biologie Molééculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Université de Strasbourg, 67083 Strasbourg cedex, France (E.W., B.G., F.P.).
Josefina-Patricia Fernandez-MorenoDepartment of Plant Sciences (J.L., A.Ad., O.L., N.A., T.T., J.-P.F.-M., A.Ah.) andChemical Research Support (K.R.), Weizmann Institute of Science, Rehovot 76100, Israel;Research and Innovation Centre, Foundation Edmund Mach, I-38010 San Michele all'Adige, Trento, Italy (J.L., F.C.);Institute for Wine Biotechnology, Stellenbosch University, Stellenbosch 7602, South Africa (J.L.);Department of Postharvest Science of Fresh Fruit, The Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel (N.A.);Department of Plant Breeding and Biotechnology, Instituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (J.-P.F.-M., A.G.); andDépartement Réseaux Métaboliques chez les Végétaux, Institut de Biologie Molééculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Université de Strasbourg, 67083 Strasbourg cedex, France (E.W., B.G., F.P.).
Emilie WidemannDepartment of Plant Sciences (J.L., A.Ad., O.L., N.A., T.T., J.-P.F.-M., A.Ah.) andChemical Research Support (K.R.), Weizmann Institute of Science, Rehovot 76100, Israel;Research and Innovation Centre, Foundation Edmund Mach, I-38010 San Michele all'Adige, Trento, Italy (J.L., F.C.);Institute for Wine Biotechnology, Stellenbosch University, Stellenbosch 7602, South Africa (J.L.);Department of Postharvest Science of Fresh Fruit, The Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel (N.A.);Department of Plant Breeding and Biotechnology, Instituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (J.-P.F.-M., A.G.); andDépartement Réseaux Métaboliques chez les Végétaux, Institut de Biologie Molééculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Université de Strasbourg, 67083 Strasbourg cedex, France (E.W., B.G., F.P.).
Bernard GrausemDepartment of Plant Sciences (J.L., A.Ad., O.L., N.A., T.T., J.-P.F.-M., A.Ah.) andChemical Research Support (K.R.), Weizmann Institute of Science, Rehovot 76100, Israel;Research and Innovation Centre, Foundation Edmund Mach, I-38010 San Michele all'Adige, Trento, Italy (J.L., F.C.);Institute for Wine Biotechnology, Stellenbosch University, Stellenbosch 7602, South Africa (J.L.);Department of Postharvest Science of Fresh Fruit, The Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel (N.A.);Department of Plant Breeding and Biotechnology, Instituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (J.-P.F.-M., A.G.); andDépartement Réseaux Métaboliques chez les Végétaux, Institut de Biologie Molééculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Université de Strasbourg, 67083 Strasbourg cedex, France (E.W., B.G., F.P.).
Franck PinotDepartment of Plant Sciences (J.L., A.Ad., O.L., N.A., T.T., J.-P.F.-M., A.Ah.) andChemical Research Support (K.R.), Weizmann Institute of Science, Rehovot 76100, Israel;Research and Innovation Centre, Foundation Edmund Mach, I-38010 San Michele all'Adige, Trento, Italy (J.L., F.C.);Institute for Wine Biotechnology, Stellenbosch University, Stellenbosch 7602, South Africa (J.L.);Department of Postharvest Science of Fresh Fruit, The Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel (N.A.);Department of Plant Breeding and Biotechnology, Instituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (J.-P.F.-M., A.G.); andDépartement Réseaux Métaboliques chez les Végétaux, Institut de Biologie Molééculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Université de Strasbourg, 67083 Strasbourg cedex, France (E.W., B.G., F.P.).
Antonio GranellDepartment of Plant Sciences (J.L., A.Ad., O.L., N.A., T.T., J.-P.F.-M., A.Ah.) andChemical Research Support (K.R.), Weizmann Institute of Science, Rehovot 76100, Israel;Research and Innovation Centre, Foundation Edmund Mach, I-38010 San Michele all'Adige, Trento, Italy (J.L., F.C.);Institute for Wine Biotechnology, Stellenbosch University, Stellenbosch 7602, South Africa (J.L.);Department of Postharvest Science of Fresh Fruit, The Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel (N.A.);Department of Plant Breeding and Biotechnology, Instituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (J.-P.F.-M., A.G.); andDépartement Réseaux Métaboliques chez les Végétaux, Institut de Biologie Molééculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Université de Strasbourg, 67083 Strasbourg cedex, France (E.W., B.G., F.P.).ORCID http://orcid.org/0000-0003-4266-9581
Fabrizio CostaDepartment of Plant Sciences (J.L., A.Ad., O.L., N.A., T.T., J.-P.F.-M., A.Ah.) andChemical Research Support (K.R.), Weizmann Institute of Science, Rehovot 76100, Israel;Research and Innovation Centre, Foundation Edmund Mach, I-38010 San Michele all'Adige, Trento, Italy (J.L., F.C.);Institute for Wine Biotechnology, Stellenbosch University, Stellenbosch 7602, South Africa (J.L.);Department of Postharvest Science of Fresh Fruit, The Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel (N.A.);Department of Plant Breeding and Biotechnology, Instituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (J.-P.F.-M., A.G.); andDépartement Réseaux Métaboliques chez les Végétaux, Institut de Biologie Molééculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Université de Strasbourg, 67083 Strasbourg cedex, France (E.W., B.G., F.P.).
Asaph AharoniDepartment of Plant Sciences (J.L., A.Ad., O.L., N.A., T.T., J.-P.F.-M., A.Ah.) andChemical Research Support (K.R.), Weizmann Institute of Science, Rehovot 76100, Israel;Research and Innovation Centre, Foundation Edmund Mach, I-38010 San Michele all'Adige, Trento, Italy (J.L., F.C.);Institute for Wine Biotechnology, Stellenbosch University, Stellenbosch 7602, South Africa (J.L.);Department of Postharvest Science of Fresh Fruit, The Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel (N.A.);Department of Plant Breeding and Biotechnology, Instituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (J.-P.F.-M., A.G.); andDépartement Réseaux Métaboliques chez les Végétaux, Institut de Biologie Molééculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Université de Strasbourg, 67083 Strasbourg cedex, France (E.W., B.G., F.P.) asaph.aharoni@weizmann.ac.il.
Instituto de Biología Molecular y Celular de Plantas · ESUniversité de Strasbourg · FRAgricultural Research Organization · ILFondazione Edmund Mach · ITInstitut de Biologie Moléculaire des Plantes · FRStellenbosch University · ZAWeizmann Institute of Science · IL
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epidermis of aerial plant organs is the primary source of building blocks forming the outer surface cuticular layer. To examine the relationship between epidermal cell development and cuticle assembly in the context of fruit surface, we investigated the tomato (Solanum lycopersicum) MIXTA-like gene. MIXTA/MIXTA-like proteins, initially described in snapdragon (Antirrhinum majus) petals, are known regulators of epidermal cell differentiation. Fruit of transgenically silenced SlMIXTA-like tomato plants displayed defects in patterning of conical epidermal cells. They also showed altered postharvest water loss and resistance to pathogens. Transcriptome and cuticular lipids profiling coupled with comprehensive microscopy revealed significant modifications to cuticle assembly and suggested SlMIXTA-like to regulate cutin biosynthesis. Candidate genes likely acting downstream of SlMIXTA-like included cytochrome P450s (CYPs) of the CYP77A and CYP86A subfamilies, LONG-CHAIN ACYL-COA SYNTHETASE2, GLYCEROL-3-PHOSPHATE SN-2-ACYLTRANSFERASE4, and the ATP-BINDING CASSETTE11 cuticular lipids transporter. As part of a larger regulatory network of epidermal cell patterning and L1-layer identity, we found that SlMIXTA-like acts downstream of SlSHINE3 and possibly cooperates with homeodomain Leu zipper IV transcription factors. Hence, SlMIXTA-like is a positive regulator of both cuticle and conical epidermal cell formation in tomato fruit, acting as a mediator of the tight association between fruit cutin polymer formation, cuticle assembly, and epidermal cell patterning.
Indexed as
FruitLipidsPhenotypePlant EpidermisPlant ProteinsPlants, Genetically ModifiedSolanum lycopersicumTranscription FactorsLipidsPlant ProteinsTranscription Factors
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