Evidence map›Paper›PMID 26443631›Full record

ReviewDevelopment (Cambridge, England)2015

Photoreceptor cell fate specification in vertebrates.

Joseph A Brzezinski, Thomas A Reh

Open access · greenAbstract readReview
In one paragraph

Review in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 172 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Single-Cell Transcriptomics onBiomedicines · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Joseph A BrzezinskiDepartment of Ophthalmology, University of Colorado Denver, Aurora, CO 80045, USA.
Thomas A RehDepartment of Biological Structure, University of Washington, Seattle, WA 98195, USA tomreh@uw.edu.
University of Colorado Denver · USUniversity of Washington · US

Funding

Self Renewal and Differentiation of Human Embryonic Stem CellsP01GM081619 · NIGMS · UNIVERSITY OF WASHINGTON · PI WARE, CAROL B · 2007 to 2017
$20.6M
Supplement to EY021482 to carry out a screen for retinal regeneration using CRISPR-Cas9 gene activation.R01EY021482 · NEI · UNIVERSITY OF WASHINGTON · PI THOMAS A REH · 2011 to 2026
$6.3M
Mechanisms of cell fate specification and competence regulation in photoreceptorsR01EY024272 · NEI · UNIVERSITY OF COLORADO DENVER · PI Joseph A Brzezinski · 2014 to 2026
$5.3M
NEI NIH HHS 1R01EY021482NEI NIH HHS R01 EY021482NEI NIH HHS R01 EY024272NEI NIH HHS R01-EY024272NIGMS NIH HHS 1P01 GM081619NIGMS NIH HHS P01 GM081619
6 · The paper itself

Abstract

Photoreceptors--the light-sensitive cells in the vertebrate retina--have been extremely well-characterized with regards to their biochemistry, cell biology and physiology. They therefore provide an excellent model for exploring the factors and mechanisms that drive neural progenitors into a differentiated cell fate in the nervous system. As a result, great progress in understanding the transcriptional network that controls photoreceptor specification and differentiation has been made over the last 20 years. This progress has also enabled the production of photoreceptors from pluripotent stem cells, thereby aiding the development of regenerative medical approaches to eye disease. In this Review, we outline the signaling and transcription factors that drive vertebrate photoreceptor development and discuss how these function together in gene regulatory networks to control photoreceptor cell fate specification.

Indexed as

AnimalsCell DifferentiationCell LineageGene Regulatory NetworksHumansNeural Stem CellsPhotoreceptor Cells, VertebrateSignal TransductionVertebratesCell fate specificationCompetenceFate potentialMultipotentPhotoreceptorRetina

Identifiers

PMID26443631
PMCPMC4631758
OpenAlexW2267772868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.