ArticleCerebral cortex (New York, N.Y. : 1991)2015
Dopamine D1 Receptor-Mediated Transmission Maintains Information Flow Through the Cortico-Striato-Entopeduncular Direct Pathway to Release Movements.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
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- Deutetrabenazine in Hyperkinetic Movement Disorders: VMAT2 Modulation From Choreiform Disorders to Hyperkinetic Dystonic Syndromes.Journal of central nervous system disease · 2026Review
- Lentiviral Vector Administration into the Mouse Brain.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Does Dysregulation Of The Indirect Pathway Contribute To The Pathophysiology Of Catatonia Through Neurotransmitter Imbalance?Clinical neuropsychiatry · 2025Article
- Rotigotine safety in real-world settings: a pharmacovigilance study using FAERS data.BMC pharmacology & toxicology · 2025Article
- Behavioral effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice.Frontiers in aging neuroscience · 2023Article
- Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals.International journal of molecular sciences · 2022Article
- Dopamine D2L Receptor Deficiency Alters Neuronal Excitability and Spine Formation in Mouse Striatum.Biomedicines · 2022Article
- Motor cortico-nigral and cortico-entopeduncular information transmission and its modulation by buspirone in control and after dopaminergic denervation.Frontiers in pharmacology · 2022Article
- D1 Receptor Mediated Dopaminergic Neurotransmission Facilitates Remote Memory of Contextual Fear Conditioning.Frontiers in behavioral neuroscience · 2022Article
- Altered Dynamic Information Flow through the Cortico-Basal Ganglia Pathways Mediates Parkinson's Disease Symptoms.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Elimination of the Cortico-Subthalamic Hyperdirect Pathway Induces Motor Hyperactivity in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Abnormal Cortico-Basal Ganglia Neurotransmission in a Mouse Model of l-DOPA-Induced Dyskinesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Activation of the mGluMolecular psychiatry · 2020Article
- Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure.Nature communications · 2020Article
- Short-term depression shapes information transmission in a constitutively active GABAergic synapse.Scientific reports · 2019Article
- Effects of vagus nerve stimulation are mediated in part by TrkB in a parkinson's disease model.Behavioural brain research · 2019Article
- Neural oscillations in the primate caudate nucleus correlate with different preparatory states for temporal production.Communications biology · 2019Article
- Behavioral and cellular dopamine DNeuropharmacology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the basal ganglia (BG), dopamine plays a pivotal role in motor control, and dopamine deficiency results in severe motor dysfunctions as seen in Parkinson's disease. According to the well-accepted model of the BG, dopamine activates striatal direct pathway neurons that directly project to the output nuclei of the BG through D1 receptors (D1Rs), whereas dopamine inhibits striatal indirect pathway neurons that project to the external pallidum (GPe) through D2 receptors. To clarify the exact role of dopaminergic transmission via D1Rs in vivo, we developed novel D1R knockdown mice in which D1Rs can be conditionally and reversibly regulated. Suppression of D1R expression by doxycycline treatment decreased spontaneous motor activity and impaired motor ability in the mice. Neuronal activity in the entopeduncular nucleus (EPN), one of the output nuclei of the rodent BG, was recorded in awake conditions to examine the mechanism of motor deficits. Cortically evoked inhibition in the EPN mediated by the cortico-striato-EPN direct pathway was mostly lost during suppression of D1R expression, whereas spontaneous firing rates and patterns remained unchanged. On the other hand, GPe activity changed little. These results suggest that D1R-mediated dopaminergic transmission maintains the information flow through the direct pathway to appropriately release motor actions.
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