ArticleInternational journal of obesity (2005)2016
Saturation of subcutaneous adipose tissue expansion and accumulation of ectopic fat associated with metabolic dysfunction during late and post-pubertal growth.
Article in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Visceral adiposity and respiratory outcomes in children and adults: a systematic review.International journal of obesity (2005) · 2022Pooled it
- Adipose Depot Changes and Associated Metabolic Risk in the Longitudinal Health Influences of Puberty Study.Pediatric obesity · 2026Trial
- Adiposity measures and pre-diabetes or diabetes in adults with hypertension in Singapore polyclinics.Journal of clinical hypertension (Greenwich, Conn.) · 2019Trial
- Performance of anthropometric indicators as predictors of metabolic syndrome in Brazilian adolescents.BMC pediatrics · 2018Trial
- Longitudinal prediction of BMI using explainable AI: integrating polygenic scores, maternal, early-life and familial factors.International journal of obesity (2005) · 2026Observational
- Specific Fat Depots and Cardiometabolic Risk and Insulin Resistance in Children With Obesity.Pediatric obesity · 2026Article
- Fasting blood glucose to high-density lipoprotein cholesterol ratio and MASLD risk: non-linear association and BMI mediation in non-diabetic adults.Frontiers in nutrition · 2026Article
- Maternal allostatic load in pregnancy is prospectively associated with child adiposity and metabolic function across infancy and early childhood.Psychoneuroendocrinology · 2025Article
- Understanding the association of intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Withaferin A Ameliorated the Bone Marrow Fat Content in Obese Male Mice by Favoring Osteogenesis in Bone Marrow Mesenchymal Stem Cells and Preserving the Bone Mineral Density.ACS pharmacology & translational science · 2024Article
- Associations of infant feeding practices with abdominal and hepatic fat measures in childhood in the longitudinal Healthy Start Study.The American journal of clinical nutrition · 2024Article
- Adipocytokines and Inflammation in Patients and a Gerbil Model: Implications for Obesity-Related and Nonobese Diabetes.Journal of diabetes research · 2024Article
- Adipose Tissue Inflammation and Pulmonary Dysfunction in Obesity.International journal of molecular sciences · 2022Review
- Uniting epidemiology and experimental models: pancreatic steatosis and pancreatic cancer.EBioMedicine · 2022Review
- Indices of insulin resistance and adiposity can detect obesity-related morbidity in pediatrics.Saudi medical journal · 2022Article
- Flavonoid-enriched extract fromFood science & nutrition · 2022Article
- Single-nuclei analysis reveals depot-specific transcriptional heterogeneity and depot-specific cell types in adipose tissue of dairy cows.Frontiers in cell and developmental biology · 2022Article
- Genetic risk score prediction of leg fat and insulin sensitivity differs by race/ethnicity in early pubertal children.Pediatric obesity · 2021Article
- Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence.Obesity (Silver Spring, Md.) · 2021Article
- Pediatric obesity-related non-alcoholic fatty liver disease: waist-to-height ratio best anthropometrical predictor.Pediatric research · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectivePuberty is a period defined by large changes in adipose tissue accumulation and distribution; however, longitudinal patterns of ectopic fat development have not been shown. We have previously shown significant declines in beta-cell function (BCF) across puberty and hypothesize that accumulation of ectopic fat deposition, particularly hepatic fat, will predict this fall. SUBJECT/
methodsWe conducted a longitudinal study and examined 2-year change in abdominal fat distribution and type 2 diabetes risk markers in 76 Hispanic children and young adults (16.1±0.5 years, 66% obese, 52% male, 51% post-pubertal). Subcutaneous abdominal adipose tissue (SAAT), visceral adipose tissue (VAT), hepatic fat fraction (HFF) and pancreatic fat fraction (PFF) were measured by 3-Tesla magnetic resonance imaging, and markers of type 2 diabetes risk were collected at fasting and during an oral glucose tolerance test (OGTT).
resultsBaseline pubertal status significantly moderated the 2-year change in ectopic fat deposition, such that VAT, HFF and PFF increased in individuals during late and post-pubertal growth, whereas children earlier in their pubertal development decreased ectopic accumulation and had less VAT accumulation (VAT: pTanner*time=0.044, 0.31±0.08 l vs 0.03±0.10 l; HFF: pTanner*time=0.007, 1.34±0.87% vs -2.61±1.11%; PFF: pTanner*time<0.001, 1.61±0.39% vs -0.96±0.50%). Independent of pubertal status, the 2-year increase in HFF and VAT significantly associated with a decline in BCF (ß=-1.04, P=0.038; ß=-1.81, P=0.020) and metabolic function, while accumulation of SAAT significantly associated with BCF (ß=1.36, P=0.012) and metabolic improvement. HFF accumulation was the only depot to significantly predict clinical markers of type 2 diabetes risk, fasting glucose and HbA1c, and circulating free fatty acid levels (ß=1.00, P=0.034; ß=1.00, P=0.015; ß=01.01, P=0.024).
conclusionsThe accumulation of SAAT defends against type 2 diabetes risk and potentially ectopic fat accumulation. Intra-abdominal VAT and HFF accumulation both associate with metabolic decline and BCF, while HFF predicts an even greater number of metabolic risk features.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.