ArticleInternational journal of obesity (2005)2016
Wheat gluten intake increases weight gain and adiposity associated with reduced thermogenesis and energy expenditure in an animal model of obesity.
Article in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults.Nature communications · 2018Trial
- Association of 37 markers of ultra-processing with all-cause mortality: a prospective cohort study in the UK Biobank.EClinicalMedicine · 2025Article
- Dietary Gluten Intake and Cardiovascular Disease Mortality in Japanese Adults in the Takayama Study.The Journal of nutrition · 2025Article
- Non-Celiac Wheat Gluten Sensitivity Model: Effects on Hepatic Morphophysiology of Wistar Rats.Nutrients · 2025Article
- Effects of dietary gluten on body weight and gut microbiota in BALB-C mice using 16 S rRNA-Based analysis.Scientific reports · 2025Article
- Optimization of Functional Gluten-Free Cake Formulation Using Rice Flour, Coconut Flour, and Xanthan Gum via D-Optimal Mixture Design.Food science & nutrition · 2024Article
- Association between major dietary patterns and obesity phenotypes in southwest China: baseline survey results from Hechuan.Frontiers in nutrition · 2024Article
- Flavour, emulsifiers and colour are the most frequent markers to detect food ultra-processing in a UK food market analysis.Public health nutrition · 2023Article
- Staple Food Preference and Obesity Phenotypes: The Regional Ethnic Cohort Study in Northwest China.Nutrients · 2022Article
- Do gluten peptides stimulate weight gain in humans?Nutrition bulletin · 2022Review
- Differential Association of Wheat and Rice Consumption With Overweight/Obesity in Chinese Adults: China Health and Nutrition Survey 1991-2015.Frontiers in nutrition · 2022Article
- Physical exercise, obesity, inflammation and neutrophil extracellular traps (NETs): a review with bioinformatics analysis.Molecular biology reports · 2021Review
- Gluten intake and metabolic health: conflicting findings from the UK Biobank.European journal of nutrition · 2021Article
- The Janus Face of Cereals: Wheat-Derived Prebiotics Counteract the Detrimental Effect of Gluten on Metabolic Homeostasis in Mice Fed a High-Fat/High-Sucrose Diet.Molecular nutrition & food research · 2019Article
- Exit Gluten-Free and Enter Low FODMAPs: A Novel Dietary Strategy to Reduce Gastrointestinal Symptoms in Athletes.Sports medicine (Auckland, N.Z.) · 2019Review
- Possible Prevention of Diabetes with a Gluten-Free Diet.Nutrients · 2018Review
- Effects of Gliadin consumption on the Intestinal Microbiota and Metabolic Homeostasis in Mice Fed a High-fat Diet.Scientific reports · 2017Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThe association between gluten and body weight is inconsistent. Previously, we showed that a gluten-free diet reduces weight gain without changing food intake in mice fed high-fat diets. In the present study, we investigated the effects of gluten intake on fat metabolism, thermogenesis and energy expenditure in mice fed a standard or high-fat diet.
methodsMice were fed four different experimental diets during 8 weeks: a control-standard diet (CD), a CD added with 4.5% of wheat gluten (CD-G), a high-fat diet (HFD) and a HFD added with 4.5% of wheat gluten (HFD-G). After 8 weeks, the mice received (99m)Tc-radiolabeled gluten orally to study gluten absorption and biodistribution or they underwent indirect calorimetry. After killing, subcutaneous and brown adipose tissues (SAT and BAT) were collected to assess thermogenesis-related protein expression. Lipid metabolism was studied in adipocyte cultures from the four groups.
resultsDespite having had the same energy intake, CD-G and HFD-G mice exhibited increased body weight and fat deposits compared with their respective controls. (99m)Tc-GLU or its peptides were detected in the blood, liver and visceral adipose tissue, suggesting that gluten can even reach extraintestinal organs. Uncoupling protein-1 expression was reduced in the BAT of HFD-G and in the SAT of CD-G and HFD-G mice. Indirect calorimetry showed lower oxygen volume consumption in CD-G and HFD-G groups compared with their controls. In HFD mice, daily energy expenditure was reduced with gluten intake. Gluten also reduced adiponectin, peroxisome proliferator-activated receptor (PPAR)-α and PPARγ and hormone-sensitive lipase in cultures of isolated adipocytes from HFD mice, whereas in the CD-G group, gluten intake increased interleukin-6 expression and tended to increase that of tumor necrosis factor.
conclusionsWheat gluten promotes weight gain in animals on both HFD and CD, partly by reducing the thermogenic capacity of adipose tissues.
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