Evidence map›Paper›PMID 26443079›Full record

ReviewChemical reviews2014

Kinases as druggable targets in trypanosomatid protozoan parasites.

Christopher Merritt, Lisseth E Silva, Angela L Tanner, Kenneth Stuart, Michael P Pollastri

Abstract readReview
In one paragraph

Review in Chemical reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
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  9. Identification of novel compounds againstComputational and structural biotechnology journal · 2025
    Article
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  16. Unravelling the myth surrounding sterol biosynthesis as plausible target for drug design against leishmaniasis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021
    Review
  17. Article
  18. Review
  19. Microorganisms · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Christopher MerrittSeattle Biomedical Research Institute , 307 Westlake Avenue North, Suite 500, Seattle, Washington 98109-5219, United States.
Lisseth E SilvaDepartment of Chemistry & Chemical Biology, Northeastern University , 417 Egan Research Center, 360 Huntington Avenue, Boston, Massachusetts 02115, United States.
Angela L TannerDepartment of Chemistry & Chemical Biology, Northeastern University , 417 Egan Research Center, 360 Huntington Avenue, Boston, Massachusetts 02115, United States.
Kenneth StuartSeattle Biomedical Research Institute , 307 Westlake Avenue North, Suite 500, Seattle, Washington 98109-5219, United States.
Michael P PollastriDepartment of Chemistry & Chemical Biology, Northeastern University , 417 Egan Research Center, 360 Huntington Avenue, Boston, Massachusetts 02115, United States.
Northeastern University · USCenter for Infectious Disease Research · US

Funding

Validation and development of trypanosomal phosphodiesterase inhibitors for treatR01AI082577 · NIAID · NORTHEASTERN UNIVERSITY · PI CAMPBELL, ROBERT KIRWAN, POLLASTRI, MICHAEL P · 2009 to 2013
$2.6M
Genome wide assessment of essential genes in Trypanosoma bruceiR01AI078962 · NIAID · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI STUART, KENNETH D · 2010 to 2012
$2.5M
NIAID NIH HHS R01 AI078962NIAID NIH HHS R01AI078962NIAID NIH HHS R01 AI082577NIAID NIH HHS R01AI082577
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsProtein Kinase InhibitorsProtein KinasesTrypanocidal AgentsTrypanosomaProtein Kinase InhibitorsProtein KinasesTrypanocidal Agents

Identifiers

PMID26443079
PMCPMC4254031
OpenAlexW2323480771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.