ArticleScientific reports2015
Comparative analyses of fecal microbiota in Tibetan and Chinese Han living at low or high altitude by barcoded 454 pyrosequencing.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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Who cites it
98 citing papers in PubMed, 184 citations in OpenAlex.
- Effects of acute severe hypobaric hypoxia on gut-muscle axis in rats.Journal of physiology and biochemistry · 2026Article
- Comparative impacts of normobaric vs. hypobaric hypoxia on tissue integrity and gut microbiota in acute high-altitude murine models.Microbiology spectrum · 2026Article
- Environmental Altitude and Host Genetics Shape Divergent Microbiota and a Conserved Resistome in Porcine Intestinal Niches.Microorganisms · 2026Article
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- Genome-resolved analysis of bile acid-metabolizing microbiota in Tibetan antelope (Pantholops hodgsonii).BMC microbiology · 2026Article
- The study on the identification of cross-boundary microbiome enterotypes between high-altitude and coastal populations and their predictive value.BMC microbiology · 2026Article
- Microbiota-gut-brain axis imbalance: a promising therapeutic target for preserving brain health in high-altitude environment.Frontiers in neuroscience · 2026Review
- Insights from the high-altitude animal gut adaptation model: mechanisms of obesity regulation via microbiota-derived metabolite homeostasis and the gut-X axis.Frontiers in microbiology · 2026Review
- Gut bacteriome alterations during high altitude exposure: a comprehensive analysis of different species.Frontiers in microbiology · 2026Review
- From mechanisms to therapeutics: molecular insights into gastrointestinal injury under high-altitude hypoxia.Frontiers in microbiology · 2026Review
- Moderate altitude exposure impacts extensive host-microbiota multi-kingdom connectivity with serum metabolome and fasting blood glucose.Virulence · 2025Article
- Alterations in the gastric and small intestinal microbiota of mice exposed to short-term and long-term hypoxia.Scientific reports · 2025Article
- Moderate altitude exposure induced gut microbiota enterotype shifts impacting host serum metabolome and phenome.BMC microbiology · 2025Article
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- A review of the relationship between gut microbiota and osteoporosis in high altitude environments.Journal of health, population, and nutrition · 2025Review
- Plateau Environment, Gut Microbiota, and Depression: A Possible Concealed Connection?Current issues in molecular biology · 2025Review
- [Changes of intestinal microflora in patients with colorectal benign and malignant tumors in high altitude area and comparison with the normal population in low altitude area].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- Human gut microbiota adaptation to high-altitude exposure: longitudinal analysis over acute and prolonged periods.Microbiology spectrum · 2025Article
- The altitudinal patterns of global human gut microbial diversity.BMC microbiology · 2025Article
38 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowledge about the impact of altitude and ethnicity on human gut microbiota is currently limited. In this study, fecal microbiota from 12 Tibetans (T group), 11 Chinese Han living in Tibet (HH group) and 12 Chinese Han living in Shaanxi province (LH group) were profiled by 454 pyrosequencing. Analysis of UniFrac principal coordinates showed significant structural changes in fecal microbiota among the three groups. There were significant differences in the composition of fecal microbiota among the three groups at phylum and genus levels. At the phylum level, the fecal samples of HH and T groups had higher relative abundances of Firmicutes, whereas the LH group had a higher relative abundance of Bacteroidetes. These changes at the phylum level reflected different dominant genus compositions. Compared with the LH group, changes of Firmicutes and Bacteroidetes were mainly due to a significant decrease of Prevotella in the HH group and were primarily attributable to significant decreases of Bacteroides and Prevotella as well as a significant increase of Catenibacterium in the T group. In conclusion, our results suggest that high altitude may contribute to shaping human gut microbiota. Genetic and dietary factors may also explain the different microbiota compositions between Tibetan and Chinese Han.
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